心型脂肪酸结合蛋白与肺动脉高压相关性临床研究.docVIP

心型脂肪酸结合蛋白与肺动脉高压相关性临床研究 　　[摘要]目的 研究心型脂肪酸?Y合蛋白（H-FABP）与肺动脉高压（PAH）的临床相关性。方法 选取2016年4月～12月我院收治的PAH患者90例（不需要区分肺动脉高压的类型），按照肺动脉压力高低分为轻、中、重三个亚组；按照病因分为慢性血栓性PAH，低氧血症性PAH、左心疾病相关性PAH。对照组为同期健康体检者80 例。采用双抗夹心ELISA 法测定患者血清H-FABP含量，同时检测肌酸激酶同工酶（CKMB），肌钙蛋白I（cTNI），NT-proBNP水平，并做统计学分析。随访时间为1年，统计全因死亡率。结果 肺动脉高压各组患者H-FABP水平明显高于对照组，差异有统计学意义（P0.05）；不同病因的肺动脉高压患者H-FABP水平的比较，差异无统计学意义（P0.05）；随访时间为1年，统计死亡发生率，发现H-FABP与死亡率具有一定相关性（P0.01）。结果H-FABP与全因死亡率相关（P0.01）。结论 PAH患者H-FABP水平较高，H-FABP水平可以评估肺动脉压力的危险程度，H-FABP为全因死亡率的独立危险因素。 　　[关键词]心型脂肪酸结合蛋白；肺动脉高压；危险程度；全因死亡率 　　[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-4721（2018）4（b）-0032-03 　　Clinical study of the correlation between heart fatty acid binding protein and pulmonary arterial hypertension 　　WANG Yu-hong LI Min▲ LI Wei 　　Department of Respiratory Diseases（VIP），Jilin Central Hospital，Jilin Province，Jilin 132011，China 　　[Abstract]Objective To study the clinical correlation between heart fatty acid binding protein （H-FABP）and pulmonary arterial hypertension（PAH）.Methods Ninety patients with PAH admitted to our hospital from April 2016 to April 2017 （without distinguishing the type of pulmonary hypertension） were selected and divided into experimental group and control group. the experimental group was divided into light，medium and heavy subgroups according to the pulmonary artery pressure.Chronic thrombotic PAH，hypoxemia PAH and left heart disease-related PAH were classified according to etiology.The control group was 80 cases of health examination in the same period. H-fabp content in serum of patients was determined by double antibody sandwich ELISA，and creatine kinase isoenzyme （ckmb），troponin I （ctni），nt-pro BNP levels were detected and analyzed statistically.The follow-up time was 18 months and all-cause mortality was counted.Results The levels of H-FABP in PAH patients were significantly higher than those in healthy controls （P0.05）.There was no significant difference in H-FABP levels among PAH patients in different etiologies（P0.05）.After 1 year fol