急性心肌梗死患者内脏素mRNA基因表达及临床相关性研究.docVIP

急性心肌梗死患者内脏素mRNA基因表达及临床相关性研究 　　【摘要】 目的：探讨急性心肌梗死患者内脏素基因在脂肪组织中表达情况，以及内脏素mRNA基因表达与患者临床相关性研究，为急性心肌梗死患者防治提供新的方法。方法：根据临床诊断标准将80例急性心肌梗死患者作为急性心肌梗死组，将100例正常人作为对照组。用RT-PCR方法检测内脏素mRNA的水平和基因的表达水平，并同时收集比较两组的临床检查数据指标。结果：急性心肌梗死患者组的血清内脏素浓度及脂肪组织中的内脏素mRNA基因表达均高于对照组（P0.05）。急性心肌梗死患者脂肪组织的mRNA的表达量与WHR、胆固醇、甘油三酯均呈正相关性（P0.05）。急性心肌梗死患者内脏素的量与机体临床的甘油三酯、胆固醇、LDL-C均呈正相关性（P0.05）。结论：急性心肌梗死患者中内脏素基因与浓度表达增高，可能是急性心肌梗死的一个独立危险因素。 　　【关键词】 急性心肌梗死； 内脏素； mRNA基因表达； 脂肪组织 　　【Abstract】 Objective：To investigate the expression of mRNA gene in the adipose tissue of patients with acute myocardial infarction，and to provide a new method for the prevention and treatment of patients with acute myocardial infarction.Method：According to the criteria of clinical diagnosis，80 patients with acute myocardial infarction were enrolled as acute myocardial infarction group， and 100 normal people were served as control group.RT-PCR method was used to detect the level of mRNA and the expression level of gene，and the clinical data of the two groups were collected and compared.Result：The plasma visfatin level and the quantitaitive of visfatin mRNA expression adipose tissues of acute myocardial infarction of patients were significantly higher than those in control group（P0.05）.The expression of mRNA in adipose tissue of patients with acute myocardial infarction was positively correlated with WHR，TG，TC（P0.05）. The amount of internal organs in patients with acute myocardial infarction was positively correlated with the clinical TG，TC，and LDL-C（P0.05）.Conclusion：In patients with acute myocardial infarction， the increased expression of the internal organs and the concentration of the internal organs may be an independent risk factor for acute myocardial infarction. 　　【Key words】 Acute myocardial infarction； Visfatin； mRNA expression； Adipose tissues 　　First-author’s address：Nanhai Hospital of the Southern Medical University，Foshan 528200，China 　　doi：10.3969/j.issn.1674-4985.2016.30.003 　　急性心肌梗死属于急性冠脉综合征一种类型，急性心肌梗死有急性ST段抬高性心肌梗死和急性非S