探讨抗甲状腺过氧化物酶抗体在甲状腺疾病诊断中临床价值.docVIP

探讨抗甲状腺过氧化物酶抗体在甲状腺疾病诊断中临床价值 　　[摘要] 目的 探讨抗甲状腺过氧化物酶抗体（TpoAb）和抗甲状腺球蛋白抗体（TgAb）在甲状腺疾病诊断中的临床价值。方法 60例患者均为方便选取该院2015年2月―2016年2月期间收治的甲状腺疾病患者，其中28例桥本氏病、16例Graves病、16例单纯甲状腺肿。所有患者均接受TpoAb、TgAb指标检测，比较不同疾病患者TpoAb、TgAb的结果。 结果 相较于单纯甲状腺肿患者来说，桥本氏病TpoAb（265.3±42.5） IU/mL、TgAb（120.4±23.5） IU/mL及Graves病患者TpoAb（158.5±14.8） IU/mL、TgAb（62.4±10.6） IU/mL在血清中含量显著较高，差异有统计学意义（P0.05）。桥本氏病TpoAb、TgAb?性率89.29%及Graves病患者TpoAb、TgAb阳性率31.25%比较单纯甲状腺肿患者阳性率12.50%显著较高，差异有统计学意义（P0.05）。 结论 抗甲状腺过氧化物酶抗体（TpoAb）和抗甲状腺球蛋白抗体（TgAb）在诊断甲状腺疾病时起着重要的作用，联合检测更能帮助区分疾病类型，为治疗和预后提供依据。 　　[关键词] 抗甲状腺过氧化物酶抗体；抗甲状腺球蛋白抗体；Graves病；桥本氏病 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）05（c）-0004-03 　　[Abstract] Objective To study the clinical value of TpoAb and TgAb in diagnosis of thyroid diseases. Methods 60 cases of patients with thyroid diseases admitted and treated in our hospital from February 2015 to February 2016 were convenient selected including 28 cases with Hashimoto disease， 16 cases with Graves disease and 16 cases with goiter， and all patients accepted the TpoAb and TgAb test， and the results of TpoAb and TgAb of patients with different diseases were compared. Results The differences in the TpoAb and TgAb contents in serum of patients with Hashimoto disease and patients with Graves diseases between were statistically significant， [（265.3±42.5） IU/mL， （120.4±23.5） IU/mL vs （158.5±14.8） IU/mL， （62.4±10.6） IU/ml]（P0.05）， and eh positive rate of TpoA and TgAb of patients with Hashimoto disease and patients with Graves diseases were obviously higher than those of patients with simple goiter， （89.29%， 31.25% vs 12.50%）， and the difference was statistically significant（P0.05）. Conclusion TpoAb and TgAb play an important role in diagnosis of thyroid diseases， and the combined test can better help to distinguish the disease types and provide reference for the treatment and prognosis. 　　[Key words] TpoAb； TgAb； Graves disease； Hashimoto disease 　　甲状腺疾病是临床上常见的疾病，当患者患上甲状腺疾病时，抗甲状腺过氧化物酶抗体（TpoAb）、抗甲状腺球蛋白抗体（TgAb）等特异性甲状腺自身抗体可能出现变化和异常[