新型降糖药物的研发跟展望-.pptVIP

Salsalate双水杨酸的降糖作用未得到再次验证 2012 年 Allison B. Goldfine,et al.A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia SIRT1的理论背景 限制热量摄入带来的寿命延长与SIRT1 有关 20 40 60 80 100 0 500 1,000 1500 0 Control Calorie restriction (40% fewer calories) McCay et al., J of Nutrition 1935 Baur et al., Nature 2006 Percentage Surviving Age (Days) 0.2 0.4 0.6 0.8 1.0 Proportion Surviving Standard diet 50 60 70 80 90 100 110 0.0 High calorie + resveratrol High calorie Time (weeks) 限制热量摄入 延长寿命，降低增龄相关疾