改良FOLFOX6新辅助化疗与术后化疗治疗进展期胃癌应用效果比较.docVIP

改良FOLFOX6新辅助化疗与术后化疗治疗进展期胃癌应用效果比较 　　[摘要]目的 比较进展期胃癌应用改良FOLFOX6新辅助化疗与术后化疗治疗的效果。方法 抽取2009年11月～2012年12月我院的进展期胃癌患者46例作为本次实验的研究对象，将其随机分为对照组和实验组。对照组23例进展期胃癌患者采取改良FOLFOX6术后辅助化疗进行治疗，实验组23例进展期胃癌患者采取改良FOLFOX6新辅助化疗进行治疗，两组进展期胃癌患者均随访3年，比较两组进展期胃癌患者的近期疗效、3年生存率、肿瘤进展时间及不良反应发生率。结果 对照组进展期胃癌患者的不良反应发生率（47.83%）显著高于实验组（21.74%）；实验组和对照组进展期胃癌患者的近期疗效、3年生存率、肿瘤进展时间比较，差异有统计学意义（P0.05）。结论 对进展期胃癌患者应用改良FOLFOX6新辅助化疗，能有效提高患者的生存时间及生存质量，且毒副作用较小。 　　[关键词]进展期胃癌；改良FOLFOX6；新辅助化疗；术后化疗；效果 　　[中图分类号]R735.2 [文献标识码]A [文章编号]1674-4721（2016）06（b）-0047-03 　　Application effect comparison of improved FOLFOX6 neoadjuvant chemotherapy and postoperative chemotherapy in treating progressive stomach cancer 　　MENG Qing-bo 　　Department of General Surgery，the Third people′s Hospital of Tonghua in Jilin Province，Tonghua 134000，China 　　[Abstract]Objective To analyze the effect of improved FOLFOX6 neoadjuvant chemotherapy and postoperative chemotherapy in progressive stomach cancer.Methods 46 progressive stomach cancer patients from November 2009 to December 2012 of our hospital were selected as study object for this study.46 progressive stomach cancer patients were random divided into control group and experimental group.23 progressive stomach cancer patients in control group were used improve FOLFOX6 postoperative chemotherapy and 23 progressive stomach cancer patients in experimental group were used improve FOLFOX6 neoadjuvant chemotherapy.The followed up of progressive stomach cancer patients in two groups were 3 years.The short term effect，three-year survival rate，time to tumor progression and the incidence rate of adverse effects of progressive stomach cancer patients in two groups were analyzed and compared.Results The incidence rate of adverse effects of progressive stomach cancer patients in control group was 47.83%，obvious higher than that was 21.74% in experimental group，and the short term effect，three-year survival rate，time to tumor progression of progressive stomach cancer patients between two groups had statis