精子DNA碎片率与男性不育关系研究.docVIP

精子DNA碎片率与男性不育关系研究 　　[摘要] 目的 分析研究精子DNA碎片率与男性不育的关系，探究不育患者年龄、精子碎片率和精液常规参数的相关性。方法 选择我院收治的男性不育患者100例作为本次研究的对象，收治时间在2013年3月～2014年6月，按照年龄将这100例患者分成三组，25～29岁组（n=33），30～35岁组（n=33），36～50岁组（n=34），使用SCD检测其精子DNA碎片率，分析检测其精液常规参数。结果 正常形态精子率和精子活力不存在相关性（r=0.65，P0.05）；精子活力和年龄存在负相关（r=-2.41，P0.05）；和精子DFI存在正相关关系（r=0.33，P0.05）。结论 随着年龄的增长精子活力会逐渐的下降，对男性的生育能力具有影响，且精液常规参数与精子DNA碎片率不存在密切的联系，故认为，精子DNA碎片检测可以在精液常规分析中应用，作为反映男性生育能力的重要指标。 　　[关键词] 精子DNA碎片率；男性不育；关系 　　[中图分类号] R711.6 [文献标识码] B [文章编号] 2095-0616（2016）09-128-03 　　[Abstract] Objective To analyze and research the relationship between sperm DNA fragmentation rate and male infertility， and to explore the relativity among age， sperm fragmentation rate and semen routine parameters of infertile patients. Methods 100 male infertility patients who were selected as the study object this time from March 2013 to June 2014 in our hospital were divided into three groups according to the age， which were 25-29 years old group（n=33）， 30-35 years old group（n=33）， and 36-50 years old group（n=34）， SCD was utilized to detect the sperm DNA fragmentation rate and analyze semen routine parameters. Results There was no correlation between normal sperm morphology rate and sperm motility（r=0.65， P0.05）. There was a negative correlation between sperm motility and age（r=-2.41， P00.05）， and positive correlation between sperm motility and sperm DFI（r=0.33， P00.05）. Conclusion With the increase of age， the sperm activity would gradually decrease， which had an effect on the male fertility. There was no close relationship between semen routine parameters and sperm DNA fragmentation rate. Therefore， sperm DNA fragmentation detection could be applied in semen routine analysis， which was considered as an important indicator of male fertility. 　　[Key words] Sperm DNA fragmentation rate， Male infertility； Relationship 　　男性不育是指育龄夫妇同居1年，未采取任何避孕措施，因男方原因造成不育的现象称为男性不育。相关的临床研究资料表明[1]，男性的年龄和自然流产具有密切的关系，男性年龄越大，意味着精子碎片率的概率越大，相关的研究资料认为，精子碎片率和男性生育力存在密切的联系，精子碎片率越高，男性的生育力则相对较弱，目前临床学术上