米非司酮对复发性子宫内膜异位症疗效及卵巢功能改善作用.docVIP

米非司酮对复发性子宫内膜异位症疗效及卵巢功能改善作用 　　[摘要] 目的 探讨米非司酮对复发性子宫内膜异位症的疗效及卵巢功能的影响。 方法 将108例复发性子宫内膜异位症患者随机分为观察组和对照组，观察组采用米非司酮片治疗，对照组采用达那唑胶囊治疗，观察两组的临床治疗效果。 结果 治疗后观察组患者性交痛、痛经改善率显著高于对照组， 差异有统计学意义（P0.05）；治疗后两组LH、FSH、E2及T与子宫内膜厚度比较，差异有统计学意义（P0.05）；观察组停药后恢复月经时间低于对照组，差异有统计学意义（P0.05）。观察组不良反应发生率显著低于对照组，差异有统计学意义（P0.05）。 结论 米非司酮治疗复发性子宫内膜异位症效果显著，改善卵巢功能，不良反应少，值得临床推广。 　　[关键词] 米非司酮；复发性子宫内膜异位症；卵巢功能；达那唑 　　[中图分类号] R711.71 [文献标识码] B [文章编号] 1673-9701（2016）10-0053-04 　　[Abstract] Objective To explore the curative effects of mifepristone on recurrent endometriosis and its effects on ovarian functions. Methods A total of 108 patients with recurrent endometriosis were randomly assigned to the observation group and the control group. The observation group was given the treatment of mifepristone， and the control group was given danazol capsule. The clinical curative effects were observed between the two groups. Results The improvement rate of dyspareunia and dysmenorrhea in the observation group after the treatment was significantly higher than that in the control group（P0.05）； the differences of LH， FSH， E2， T and thickness of endometrium compared between the two groups after the treatment were statistically significant（P0.05）； the time of resuming menstruation in the observation group after withdrawal of drugs was shorter than that in the control group（P0.05）. The incidence of adverse reactions in the observation group was significantly lower than that in the control group， the difference was statistically significant（P0.05）. Conclusion Mifepristone in the treatment of recurrent endometriosis has significant effects， and is able to improve ovarian functions with few adverse reactions， which is worthy of clinical promotion. 　　[Key words] Mifepristone； Recurrent endometriosis； Ovarian functions； Danazol 　　复发性子宫内膜异位症[1，2]是指经过手术或药物成功治疗一段时间后，子宫内膜异位症的病灶和症状重新出现。由于患者心理抗拒再次手术，因而选择副作用小、安全性高、疗效好的药物治疗成为临床医生面临的首要问题。以达那唑为主的假绝经疗法在治疗子宫内膜异位症方面取得了满意的效果，但是达那唑雄激素效应和低雌激素反应[3]限制了其临床应用。米非司酮是一种抗糖皮质和抗孕酮的类固醇，能够与受体结合抑制孕酮和卵巢功能，