米非司酮对50例子宫肌瘤切除术后患者血清促卵泡激素雌二醇和孕酮水平及预后影响.docVIP

米非司酮对50例子宫肌瘤切除术后患者血清促卵泡激素雌二醇和孕酮水平及预后影响 　　摘 要 目的： 探讨米非司酮对子宫肌瘤切除术后患者血清促卵泡激素（follicle-stimulating hormone，FSH）、雌二醇（estradiol，E2）、孕酮（progesterone，P）及预后的影响。方法： 选取我院子宫肌瘤患者100例，随机分为观察组与对照组，观察组于月经第一天起每晚口服米非司酮10 mg，连服90 d，停药后2 d内行子宫肌瘤切除术，术后口服米非司酮90 d；对照组手术前后均未口服米非司酮及类似物。采用酶联免疫吸附试验（ELISA）法测定血清FSH、E2、P水平。结果： 治疗后，观察组子宫体积与最大子宫肌瘤体积均明显小于对照组与治疗前，子宫与最大子宫肌瘤体积缩小率均明显大于对照组（P0.05）。观察组血清FSH、E2、P水平明显低于对照组与治疗前（P0.05）。服药期间出现头痛、头晕与恶心症状均于停药后缓解。术后随访6个月，观察组复发率明显低于对照组（P0.05）。结论： 米非司酮有助于显著降低子宫肌瘤切除术后血清FSH、E2、P水平，降低复发率，从而改善预后状况。 　　关键词 米非司酮 子宫肌瘤切除术 促卵泡激素 雌二醇 孕酮 　　中图分类号：R979.2； R737.33 文献标识码：A 文章编号：1006-1533（2016）11-0025-03 　　The effect of mifepristone on the levels of serum FSH， estradiol and progesterone and prognosis of 50 cases of the patients after undergoing myomectomy* 　　ZHANG Huiyun**， QIU Meiying， LIU Weiguo（Department of Gynecology， Maternal and Child Health Care Hospital of Heyuan City， Guangdong Province， Heyuan 517000， China） 　　ABSTRACT Objective： To study the effect of mifepristone on the levels of serum follicle - stimulating hormone （FSH）， estradiol （E2） and progesterone （P） and the prognosis of the patients after undergoing myomectomy. Methods： One hundred patients with uterine fibroids were selected from our hospital and randomly divided into an observation group and a control group with 50 cases each. The observation group was given mifepristone every night on the first day of menstruation for 90 days， underwent myomectomy within two days of drug withdrawal and postoperatively given mifepristone again for 90 days. The control group was given neither mifepristone nor its analogues before and after operation. The levels of serum FSH， E2 and P were detected by enzyme-linked immunosorbent assay （ELISA）. Results： After treatment， the volumes of uterus and the largest uterine fibroids were significantly smaller in the observation group than the control group and post-therapy than pre-therapy. The shrink rates of the volumes of uterus and the largest uterine fibroids were significan