窒息新生儿血清磷酸肌酸激酶同工酶与肌钙蛋白I变化及其临床意义.docVIP

窒息新生儿血清磷酸肌酸激酶同工酶与肌钙蛋白I变化及其临床意义 　　[摘要] 目的 探讨窒息新生儿血清磷酸肌酸激酶同工酶（CK-MB）与肌钙蛋白I（cTnI）的变化及其临床意义。 方法 选取本院2011年1月～2013年11月的117例窒息新生儿作为观察组，其中轻度窒息组70例，重度窒息组47例。选取同期出生的128例无窒息新生儿作为对照组，比较3组的CK-MB及cTnI水平。 结果 轻度窒息组和重度窒息组的CK-MB、cTnI水平显著高于对照组，差异有统计学意义（P0.05）。重度窒息组的CK-MB、cTnI水平显著高于轻度窒息组，差异有统计学意义（P0.05）。4 d窒息新生儿的CK-MB、cTnI水平显著低于1、2、3 d窒息新生儿，差异有统计学意义（P0.05）。3 d窒息新生儿的CK-MB、cTnI水平显著低于1、2 d窒息新生儿，差异有统计学意义（P0.05）。2 d窒息新生儿的CK-MB、cTnI水平显著低于1 d窒息新生儿，差异有统计学意义（P0.05）。 结论 窒息新生儿的缺氧程度同心肌损害程度成正比，血清CK-MB及cTnI水平可以作为窒息新生儿心肌损害的诊断指标。 　　[关键词] 窒息新生儿；血清磷酸肌酸激酶同工酶；肌钙蛋白I 　　[中图分类号] R722.12 [文献标识码] A [文章编号] 1674-4721（2015）07（c）-0016-03 　　Change and clinical significance of serum creatine phosphate kinase and troponin I in asphyxial newborns 　　ZHANG Guo-ying 　　Department of Pediatrics，People′s Hospital of Baoan District in Shenzhen City，Shenzhen 518101，China 　　[Abstract] Objective To explore the changes and clinical significance of serum creatine phosphate kinase （CK-MB） and troponin I （cTnI） in asphyxial newborns. Methods 117 asphyxial neonates from January 2011 to November 2013 in our hospital were selected as the observation group.Among them，70 cases were in mild asphyxia and 47 cases were in severe asphyxia.128 neonates without asphyxia in the same period were selected as the control group.The level of CK-MB and cTnI among three groups was compared. Results The level of CK-MB and cTnI in the severe asphyxia group and mild asphyxia group was higher than that in the control group respectively，with significant difference（P0.05）.The level of CK-MB and cTnI in the severe asphyxia group was higher than that in the mild asphyxia group，with significant difference（P0.05）.The level of CK-MB and cTnI in four-day-old children patients was lower than that in one，two and three-day-old children，with significant difference（P0.05）.The level of CK-MB and cTnI in three-day-old children patients was lower than that in one and two-day-old children，with significant difference（P0.05）.The level of CK-MB and cTnI in two-day-ol