稽留流产原因分析以及早期诊断.docVIP

稽留流产原因分析以及早期诊断 　　【摘要】目的：通过统计学方法探讨Ct、Uu、TORCH感染与稽留流产的相关性以及妊娠相关血浆蛋白-A（PAPP-A）、孕激素（Progesterone， P）水平在稽留流产早期诊断中的价值。方法：选取2014年7月到12月宝鸡市妇幼保健院稽留流产病例107人以及门诊同期正常妊娠病例150人，通过免疫法和培养法对孕妇宫颈分泌物进行感染（Ct、Uu和TORCH）检测， 统计感染所占稽留流产病例的比例从而确定感染与稽留流产的相关性；同时通过用酶联免疫吸附法检测稽留流产患者和同期门诊正常妊娠病例血清孕酮和妊娠相关蛋白含量。结果：稽留流产患者Ct或/和Uu的感染率为56%，正常妊娠孕妇感染率为66%；稽留流产患者的TORCH感染率为178%，正常妊娠孕妇感染率为53%；稽留流产患者血清P和PAPP-A含量分别为（2337±589）nmol/L和（5958±832）U/L；而对应正常妊娠病例的含量分别为（7547±1763）nmol/L和（16807±257）U/L。结论：感染和稽留流产有很高的相关性，是造成稽留流产病因之一；早期检测P和PAPP-A含量有利于稽留流产的早期诊断。 　　【关键词】稽留流产；感染；孕酮；妊娠相关血浆蛋白 　　Thereason analysis and early diagnosis of missed abortionWEN Yunxia， QI Lianfang， JIANG Gaili. Department of Family Planning， Maternal andChild Health Hospital of Baoji City， Baoji 721000， Shanxi， China 　　【Abstract】Objectives： To investigate the relevance between Ct， Uu and TORCH infections and missed abortion by statistical methods and the value of the concentration of pregnancy-associated plasma protein-A （PAPP-A） and progesterone （Progesterone， P） in the early diagnosis of missed abortion. Methods： 107 cases of missed abortion diagnosed in Baoji City Maternal and Child Health Hospital from July to December 2014； meanwhile， 150 normal pregnant women in the same period were selected as control group. The infection of Ct， Uu and TORCH was detected by immunoassay and culture of cervical secretions from pregnant women； then， it took advantage of statistical method to determine the relevance between Ct Uu and TORCH infections and missed abortion. The concentration of serum progesterone and pregnancy-associated protein was determined by enzyme linked immunosorbent assay （ELISA）. Results： Infection rate of Ct and/or Uu in missed abortion pregnancies was 56%； however the corresponding rate in normal pregnant women was 6.6%； the TORCH infection rate in missed abortion pregnant women was 36.5% and that in normal pregnant women was 6%； PAPP-A and P concentrations in abortion pregnancies were 23.37 ± 5.89n mol / L and 59.58 ± 8.32 U / L， and i