细菌感染时唾液酸红细胞分布宽度变化分析.docVIP

细菌感染时唾液酸红细胞分布宽度变化分析 　　[摘要] 目的 回顾性分析全血和脓液细菌培养阳性患者血清唾液酸（SA）、全血红细胞分布宽度变异系数（RDW-CV）检测值，观察两者在细菌感染时的变化，对细菌感染的诊断价值。 方法 选取145例血培养细菌生长患者为血液组，118例脓液细菌培养阳性患者为脓液组，同期健康体检者201例为对照组。分析其血清SA、RDW-CV变化，比较革兰氏阳性（G+）菌和革兰氏阴性（G-）菌感染、全身和局部感染时各项指标的差异及三组间差异。通过比较ROC曲线下面积（AUC），评价血清SA和RDW-CV对细菌感染的诊断价值。 结果 细菌感染时，血清SA和RDW-CV无性别差异（P0.05），血清SA在血液组与脓液组间无差异（P0.05），与对照组比较均有显著性差异（P均0.05），脓液组中血清SA有显著差异（P0.05）。SA诊断血液、脓液细菌感染的AUC分别为0.663和0.640，RDW-CV诊断血液细菌感染的AUC为0.673，对脓液细菌感染无诊断价值。 结论 细菌感染时，血液组和脓液组血清SA无明?@差异，但均明显高于对照组。血液组RDW-CV高于脓液组，两组均高于对照组。临床上可将SA和RDW-CV作为炎症性参考指标。 　　[关键词] 细菌；唾液酸；红细胞分布宽度；感染 　　[中图分类号] R378 [文献标识码] B [文章编号] 1673-9701（2017）07-0118-04 　　[Abstract] Objective To retrospectively analyze the detection value of serum sialic acid （SA） and whole red blood cell distribution width variation coefficient（RDW-CV） in the patients with positive whole blood and pus bacterial culture， and to observe the changes in bacterial infection， as well as the diagnostic value of bacterial infection. Methods 145 patients who were given blood culture for bacterial growth were selected as the blood group， and 118 patients with positive pus bacterial culture were selected as the pus group. 201 healthy subjects during the same period were selected as the control group. The differences of each index were compared in Gram-positive （G+） and Gram-negative （G-） bacterial infections， and systemic and local infection， and the differences between the three groups were compared. The diagnostic value of serum SA and RDW-CV in bacterial infection was evaluated by comparing the area under the ROC curve （AUC）. Results There was no gender difference between serum SA and RDW-CV in bacterial infection （P0.05）. There was no significant difference in serum SA between the blood group and the pus group（P0.05）. Compared with the control group， there were significant differences（P0.05）， but there was a significant difference in serum SA in the pus group（P0.05）. The AUC of blood and pus bacterial infection by SA diagnosis was 0.663 and 0.64