半乳糖凝集素-3、同型半胱氨酸及超敏c反应蛋白与心房颤动左心房结构重构关系的探讨-内科学(心血管病)专业论文.docxVIP

Abst Abstract IV IV ABSTRACT Objective: In this study, we investigate that the role of galactoselectin-3(Galectin-3), high sensitive C-reactive protein(hs-CRP) and homo cysteine (HCY) play in atrial structural remodeling via their correlation with left atrial volume index(LAVI). To promote better understanding of pathogenesis and risk factors of atrial fibrillation, provide more ideas for the prevention and treatment of atrial fibrillation in clinic. Methods: We included 107 AF patients(51 male and 56 female, mean age 65.2±8.6) from the second affiliated hospital of Nanchang university between Sep,2013 and Sep,2014, including 61 persistent AF and 46 paroxysmal AF. At the same time, 40 sinus rhythm( basic date similar to the AF group )were included as controls. Baseline characteristics were recorded. Fasting blood were siphoned in the second morning to detect serum levels of hepatorenal function, glucose, blood lipid, thyroid function, BNP, etc. All patients underwent electrocardiogram and 24 hour dynamic electrocardiogram. LAD, LVEF, LAV, etc. were calculated by echocardiographic method and LAVI was calculated. Galectin-3 and HCY level were measured by ELISA, hs-CRP was measured by immunoturbidimetry. Patients were classified into three groups(persistent AF group, paroxysmal AF group, controls). The comparisons about Galectin-3, HCY, hs-CRP were performed among three groups. Pearson correlation analysis, Multiple linear regression analysis and logistic regression analysis were used to analyze the relationship among Galectin-3, HCY, hs-CRP and LAVI. Results: 1 、 Serum Galectin-3 in persistent AF group(1567.1±185.3 pg/ml) was significantly higher than these in paroxysmal AF group(1482.5±107.3 pg/ml)and controls(1389.4±121.2 pg/ml) (P＜0.05), and so was in paroxysmal AF group than this in controls(P＜0.05); serum hs-CRP in persistent AF group(3.85±3.01mg/L) was significantly higher than these in paroxysmal AF group (2.84±2.21mg/L) and controls PAGE PAGE VI s