苦参不同提取液对慢性湿疹治疗效果研究.docVIP

苦参不同提取液对慢性湿疹治疗效果研究 　　摘要：目的：研究苦参不同提取液对慢性湿疹临床治疗的效果。方法：选择患有慢性湿疹的病人150例，随机分为5组，4个治疗组使用苦参的不同提取液和不同给药方式进行临床治疗，对照组给予西替利嗪口服，观察临床治疗效果及不良反应等情况。结果：4个治疗组相对于对照组疗效较好，具有显著意义（P0.05）；其中使用SBE提取液外用方法对湿疹患者治疗时治疗效果最好，苦参外用会导致四肢麻痹的不良反应，而苦参内服会出现胃肠道的反应。结论：治疗效果是将SBE提取液外用最好，可以减轻皮肤瘙痒，不会出现胃肠道的反应，且见效快。 　　关键词：苦参；慢性湿疹；治疗效果 　　中图分类号：R758.23文献标识码：B文章编号：1673-7717(2012)03-650-03 　　Study on Clinical Effect of Chronic Eczema Treating with 　　Different Extraction Solvents from Sophora flavescens 　　WU Wei?ming1,SUN Zhong?min1,CHEN Li?jia1, HUANG Tian?yi2 　　(1.The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027,Zhejiang,China; 　　2.The Kindness Rehabilitation Hospital of Zhejiang, Hangzhou 310012,Zhejiang,China) 　　Abstract:Objective: Extraction Solvents from Sophora flavescens were observed on its effect on chronic eczema. Methods: 150 cases of chronic eczema were chosen and randomly divided into five groups. The four treatment groups took modified different extraction Solvents from Sophora flavescens and manners of administration, and the control group took cetirizine orally. The therapeutic effects and complications were observed after treatment. Results: The clinical efficacy of the four treatment groups was superior to the control group (P0.05).The best treatment was topical application with SBE extraction of Solvents. Topical Sophora flavescens would caused limb paralysis side effects, and oral administration of Sophora flavescens would occured gastrointestinal reactions. Conclusion： The best treatment was topical application with SBE extraction of Solvents，which can reduce skin itching, and gastrointestinal reactions would not occur, with fast effect. 　　Key words:Sophora flavescens；chronic eczema；clinical effect 　　 　　收稿日期：2011-10-15 　　作者简介：吴伟明(1976-)，男，浙江龙游人，主管药师，学士，研究方向：医院制剂及药物分析。苦参（Sophora flavescens）是豆科苦参属的植物。主要分布在朝鲜、日本、俄罗斯、印度以及中国大陆的南北各省市区等地，一般生长于海拔约1500米的地区，多生长在灌木林、沙地、草地、山坡中，目前尚未由人工栽培。苦参具有清热燥湿、利尿、杀虫的功效，可以用于治疗热痢、便血、湿疮、湿疹、皮肤瘙痒、赤白带下、阴肿阴痒、疥癣麻风、黄疸尿闭等疾病；外用可以治疗滴虫性阴道炎[1]。笔