脾多肽注射液联合化疗对晚期胃癌免疫功能和临床疗效影响.docVIP

脾多肽注射液联合化疗对晚期胃癌免疫功能和临床疗效影响 　　[摘要] 目的 探讨脾多肽注射液在晚期胃癌化疗中的作用。方法 经病理学或细胞学检查确诊的晚期胃癌患者随机分为实验组与对照组，对照组单纯采用化疗，实验组在化疗方案基础上加用脾多肽注射液，比较两组化疗前后临床疗效、免疫功能（T细胞亚群、IFN-γ、IL-2、IL-6）和毒副反应的差异。 结果 实验组、对照组近期有效率分别为46.67%、36.67%，差异无统计学意义（P0.05），实验组化疗后免疫细胞、IL2及IFN-γ水平较化疗前升高，IL-6水平降低，差异有统计学意义（P 0.05），对照组化疗后免疫细胞水平较化疗前减少，差异有统计学意义（P0.05），两组骨髓抑制不良反应的发生率比较差异有统计学意义（P0.05）。结论 脾多肽注射液能够提高机体免疫功能，减轻化疗时的不良反应，具有增效减毒的作用。 　　[关键词] 胃癌；脾多肽注射液；免疫功能 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1674-0742（2015）05（b）-0132-03 　　Effects of the Lienal Polypeptide Injection Combined with Chemotherapy on Patients with Advanced Gastric Carcinoma 　　ZHANG Yan-fang，NIU Chun-lian 　　Department of Oncology， Anyang tumour hospital， Anyang， Henan， 455000 China 　　[Abstract] Objective To investigate the effects of Lienal Polypeptide Injection combined with chemotherapy on patients immune function and adverse reactions with advanced gastric carcinoma. Methods The patients with advanced gastric carcinoma were divided into control group（treated with chemotherapy）and observation group （treated with Lienal Polypeptide Injection and chemotherapy）.The clinical effects，immune function（T cell subpopulations in blood，cytokins such as， IFN-γ、IL-2、IL-6 in serum） and adverse reactions in the two groups were compared.Results The response rate of treatment group and control group was 46.67%and 36.67% respectively， without significant difference. T cell subpopulations in blood，cytokins such as， IFN-γ、IL-2 in serum were increased in the treatment group after treatment， while IL-6 was decreased （P0.05）. T cell subpopulations in blood were decreased in control group after treatment（P0.05）.There was significant difference in adverse reactions between the two groups.Conclusion The Lienal Polypeptide Injection can improve immune function，decrease adverse reactions during cancer chemotherapy. 　　[Key words] Gastric carcinoma； Lienal Polypeptide Injection； Immune function 　　近年来，胃癌发病率逐年上升，并且已跃居消化道肿瘤死因的首位[1]。大多数患者就诊时已属晚期，化疗成为主要治疗方法，但化疗造成的免疫功能下降及骨髓抑制往往限制临床的治疗。