葡萄球菌重症感染68例临床分析.docVIP

葡萄球菌重症感染68例临床分析 　　[摘要] 目的 分析和总结68例金黄色葡萄球菌重症感染病例的感染特点以及治疗经验。方法 整群选取2012年3月―2014年7月该院收治的金黄色葡萄球菌感染病例68例，统计和分析葡萄球菌感染患者的临床数据。结果 该院金黄色葡萄球菌感染的科室主要分布在脑外科、肿瘤科、ICU、儿科，分别占29.4%、20.6%、17.6%、14.7%；感染部位主要是肺部、伤口、血液、皮肤软组织、泌尿系，分别占47.1%、17.6%、14.7%、8.8%%、5.9%；金黄色葡萄球菌耐药性最高的四种抗生素为：青霉素、红霉素、阿奇霉素、克林霉素；金黄色葡萄球菌敏感率最高的四种抗生素为万古霉素、利福平、替考拉宁和呋喃妥因；根据该院金黄色葡萄球菌药敏结果，30例感染患者采取万古霉素治疗，均痊愈出院；12例感染患者采取利福平、呋喃妥因治疗，均痊愈出院；8例感染患者采取利福平、替考拉宁治疗，均痊愈出院；18例感染患者采取替考拉宁、呋喃妥因治疗，均痊愈出院。结论 金黄色葡萄球菌感染分布于各个科室，侵染途径多样，应结合药敏试验结果，给予患者合适抗生素治疗，提高治疗效果，促进患者痊愈。 　　[关键词] 重症感染；金黄色葡萄球菌；药敏试验 　　[中图分类号] R753 [文献标识码] A [文章编号] 1674-0742（2015）06（c）-0068-02 　　[Abstract] Objective To investigate the characteristics and experience of treatment of severe infection of staphylococcus aureus. Methods 68 patients with severe infection of staphylococcus aureus admitted to our hospital from March 2012 to July 2013 were selected and their clinical data were analyzed. Results Patients mainly distributed in department of cerebral surgery，oncology， ICU， and pediatric， accounting for 29.4%、20.6%、17.6%、14.7%， respectively. The main infection sites were lung， wounds， blood， urinary system， accounting for 47.1%、17.6%、14.7%、8.8%%、5.9%， respectively. The four highest of the antibiotic resistance were penicillin， erythromycin， azithromycin， clindamycin. The four highest of the sensitive antibiotic were rifampicin， vancomycin， teicoplanin and nitrofurantoin. According to drug sensitive test， all patients given appropriate antibiotics （30 with vancomycin， 12 with rifampicin and nitrofurantoin， 8 with rifampicin and teicoplanin， 18 with teicoplanin and nitrofurantoin） were recovered completely. Conclusion Staphylococcus aureus infection distributes in various departments， and the way of infection varies. Patients given appropriate antibiotic therapy should be combined with the results of drug sensitivity test to enhance the treatment effect and promote the patient recover. 　　[Key words] Severe infection； Staphylococcus aureus； Drug sensitivity test 　　目前，院内感染成为医