肺癌患者外周血中期因子水平表达与预后关系研究.docVIP

肺癌患者外周血中期因子水平表达与预后关系研究 　　[摘要] 目的 研究肺癌患者外周血中期因子（MK）水平表?_与预后的关系。方法 选取我院收治的肺癌患者33例作为肺癌组，选取同期收治的肺炎患者39例作为肺炎组，选取同期健康体检者35例作为健康组，分别在清晨空腹时抽取外周静脉血，进行MK水平检测，研究MK水平表达与预后的关系。 结果 肺癌组、肺炎组患者的外周血MK水平高于健康组，肺癌组患者的外周血MK水平高于肺炎组，差异有统计学意义（P0.05）。非小细胞肺癌患者中，I期、IIA-B期、IIIA-B期患者的外周血MK水平均低于IV期，I期、IIA-B期患者的外周血MK水平均低于IIIA-B期，I期患者的外周血MK水平低于IIA-B期，差异有统计学意义（P0.05）。肺癌患者化疗后外周血MK水平低于化疗前，差异有统计学意义（P0.05）。 结论 肺癌患者外周血中期因子在不同病理分期患者中水平表达不同，病情越严重的患者MK表达越高，且可化疗后患者MK水平有所降低，因此说明MK与患者的预后有相关性。 　　[关键词] 肺癌；肺炎；中期因子；预后 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 2095-0616（2017）05-155-04 　　[Abstract] Objective To study the relationship between the expression of Midkine （MK） and prognosis in patients with lung cancer. Methods 33 cases of patients with lung cancer cured in our hospital were selected as lung cancer group，39 patients with pneumonia during the same time were selected as the pneumonia group，35 cases of healthy people were selected as healthy group.Respectively，in the early morning fasting，peripheral venous blood was collected，MK level detection was carried on， and the relationship between the expression of MK and prognosis were explored. Results The levels of MK in peripheral blood of patients with lung cancer and pneumonia were higher than those in healthy group，the MK level in peripheral blood of patients with lung cancer was higher than that in pneumonia group，and the difference was statistically significant（P0.05）.In patients with non-small cell lung cancer，I stage，IIA-B stage and IIIA-B stage in patients with peripheral blood levels of MK were lower than IV，the level of MK in peripheral blood of patients with IIA-B stage I were lower than IIIA-B，the level of MK in peripheral blood of I patients was lower than that of IIA-B，and the differences were statistically significant（P 　　[Key words] Lung cancer；Pneumonia；Midkine；Prognosis 　　肺癌是最常见的恶性肿瘤之一，对人类健康构成了巨大的威胁，并且随着环境、生活习惯的改变，肺癌的发病率在不断上升[1]。同时目前人们健康意识薄弱，在自觉症状进行检查时，肺癌已经处于中晚期，难以保证治疗效果。因此对肺癌的早期诊断方法进行探讨仍然具有重要临床价值。肺癌标志物是早期检测肺癌的重要手段，目前常用的肿瘤标志物类型较少，因此开发新型的肿瘤标志物仍然是