耐碳青酶烯类肺炎克雷伯菌替加环素MIC药敏试验和临床特点分析.docVIP

耐碳青酶烯类肺炎克雷伯菌替加环素MIC药敏试验和临床特点分析 　　【摘要】 目的：应用微量肉汤稀释法（MIC）药敏试验测定耐碳青霉烯类肺炎克雷伯菌对替加环素的耐药率，并分析耐药菌的临床特点。方法：搜集2014年11月-2016年4月本院微生物室从不同病区各种临床标本分离的耐碳青酶烯类肺炎克雷伯菌38株（CRKP），应用微量肉汤稀释法进行替加环素药敏试验，从患者年龄、性别、标本类型、原发病、抗生素使用情况等方面对比，分析临床特点与替加环素耐药的相关性。结果：在38株CRKP中筛选到6耐替加环素耐药菌，耐药率为15.8%。耐药性与患者年龄有关（P0.05）。结论：耐替加环素的耐碳青霉烯类肺炎克雷伯菌已经出现，耐药株多见于老年患者。 　　【关键词】 肺炎克雷伯菌； 耐碳青霉烯； 替加环素 　　MIC Antimicrobial Susceptibility Test to Tigecycline and Clinical Analysis of Carbapenem Resistant Klebsiella Pneumoniae/ZHENG Ya-qing，CHEN Dong-jie，LI Hong-ru，et al.//Medical Innovation of China，2017，14（16）：028-031 　　【Abstract】 Objective：To study the drug resistance rate of carbapenem resistant Klebsiella pneumoniae to Tigecycline by using broth Microdilution Method（MIC）.Method：From November 2014 to April 2016 ward room microorganisms isolated from different clinical samples by carbapenem resistant Klebsiella pneumoniae 38 strains （CRKP） were collected in our hospital，the application of micro broth dilution method of Tigecycline susceptibility test，the age and sex of the patients， specimen type， primary disease， antibiotic use and other aspects were compared，the clinical features and add ring correlation resistance were analysed.Result：In 38 strains of CRKP，the resistance to Tigecycline were 6 strains，and the drug resistance rate was about 15.8%.Drug resistance was associated with patient age（P0.05）.Conclusion：The carbapenem resistant Klebsiella pneumoniae to Tigecycline has been found，and the resistant strains are more common in elderly patients. 　　【Key words】 Klebsiella pneumoniae； Carbapenem resistant； Tigecycline 　　First-author’s address：Provincial Clinical Medical College of Fujian Medical University，Fuzhou 350000，China 　　doi：10.3969/j.issn.1674-4985.2017.16.008 　　替加?h素是新上市的甘氨酰环素类抗生素，是临床治疗耐碳青酶烯类肺炎克雷??菌（Carbapenem resistant Klebsiella pneumoniae，CRKP）感染的首选药物[1]。但是对替加环素和碳青酶烯类抗生素耐药的肺炎克雷伯菌（Tigecycline resistant Klebsiella pneumoniae，TRKP）感染病例有逐年上升趋势，且该耐药菌在院内传播和爆发的形势越来越严峻[2]。TRKP的出现可能使CRKP感染陷入无药可用的困境，严重威胁CRKP感染患者的预