芪参益气滴丸联合曲美他嗪治疗左室射血分数保留心衰临床研究.docVIP

芪参益气滴丸联合曲美他嗪治疗左室射血分数保留心衰临床研究 　　摘要：目的 探讨芪参益气滴丸联合曲美他嗪治疗左室射血分数保留心力衰竭的临床疗效。方法 将我院2012年5月―2013年2月收治的左室射血分数保留心衰患者120例分为3组。对照组40例，给予常规抗心衰治疗；芪参益气滴丸组40例，在常规治疗的基础上加用芪参益气滴丸；联合治疗组40例，在常规治疗基础上加用芪参益气滴丸及曲美他嗪。治疗3个月后观察心功能分级（NYHA）、6 min步行距离、舒张早晚期血流峰值比值（E/A值）、二尖瓣口舒张早期血流峰值速度E与二尖瓣环舒张早期峰值速度e的比值（E/e）、脑钠肽（BNP）水平。结果 芪参益气滴丸组、联合治疗组总有效率均高于对照组，而联合治疗组优于芪参益气滴丸组（P0.05）。芪参益气滴丸组及联合治疗组治疗前后6 min步行距离明显延长，E/A显著增加，E/e显著降低，BNP水平明显下降（P0.05）。结论 在常规治疗心衰基础上联合芪参益气滴丸及曲美他嗪可进一步改善左室射血分数保留心衰患者的心功能，提高患者生活质量。 　　关键词：心力衰竭；曲美他嗪；左室射血分数保留；芪参益气滴丸；脑钠肽 　　中图分类号：R541.6 R289.5 文献标识码：B doi:10.3969/j.issn.1672 1349.2014.05.021 文章编号：1672 1349（2014）05 0557 02 　　 　　 　　Clinical Study with Combination of QiShen YiQi Dripping Pill with Trimetazidine in Patients in Heart Failure with Preserved Ejection Fraction 　　Li Xin//The Third Hospital of Xingtai,Hebei(Xingtai 054000) 　　 　　 　　Abstract：Objective To investigate the effects of Qishen Yiqi dripping pills(QYDP) and trimetazidine for treatment of heart failure with preserved ejection fraction(HFPEF).Methods One hundred and twenty patients with HFPEF were randomly divided into three groups:Control group (n=40) treated by routine treatment of heart failure, QYDP group（n=40）treated by routine treatment plus QYDP,combination treatment group（n=40）treated by routine treatment plus QYDP and trimetazidine.The New York Heart Association (NYHA) functional class and six minute walking test (6 min WT) and Btype natriuretic peptide (BNP) were recorded,ratio of maximal velocity of bicuspid blood flow in the early（E） and advanced（A） stages of left ventricle diastole(E/A)and early diastolic peak velocity/tissue early distolic velocity ratio (E/e’) were detected by echocardiogram before and after treatment.Results The effective rate and the total effective rate in QYDP group and combination treatment group were higher than those in control group，while those in combination treatment group were better than QYDP group (P0.05) .E/A，E/e’in QYDP group and combination treatment group after treatment i