血清淀粉样蛋白A和C―反应蛋白对儿童支原体肺炎诊断价值.docVIP

血清淀粉样蛋白A和C―反应蛋白对儿童支原体肺炎诊断价值 　　[摘要] 目的 探讨血清淀粉样蛋白A（SAA）和C-反应蛋白（CPR）检测对儿童支原体肺炎的诊断价值。 方法 回顾性分析2016年1～12月保定市第一中心医院因肺部感染住院患儿159例的临床资料，其中支原体感染患儿124例（支原体感染组）、细菌感染患儿35例（细菌感染组），选择同期健康体检儿童20例作为对照组。分别测定和分析三组SAA和CRP水平，并应用ROC曲线进行分析。 结果 三组间SAA、CRP比较差异有统计学意义（P 0.05）。SAA和CRP诊断儿童肺炎支原体感染的ROC曲线下面积分别为0.95、0.33；诊断儿童细菌感染的ROC曲线下面积分别为0.88、0.86。 结论 SAA检测对诊断儿童肺炎支原体感染和细菌感染的准确性均较高；CRP检测对诊断儿童细菌感染准确性较高，但对于鉴别诊断儿童肺炎支原体的意义较小。SAA检测可用于儿童肺炎支原体感染的鉴别诊断，应在临床中广泛应用；CRP检测对于儿童肺炎支原体感染的价值仍需继续深入研究。 　　[关键词] 血清淀粉样蛋白A；C-反应蛋白；肺炎支原体感染；受试者工作特征曲线 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1673-7210（2017）09（a）-0134-04 　　[Abstract] Objective To investigate the clinical value of serum amyloid A protein （SAA） and C-reactive protein （CRP） on diagnosis of children with Mycoplasma pneumoniae （Mp） infection. Methods From January to December 2016， in East Branch of Baoding First Central Hospital， the data of 159 hospitalized children with pulmonary infection were retrospectively analyzed， including 124 Mp infection children （Mp infection group）， 35 bacterial infection children （bacterial infection group）， 20 healthy children were selected as control group at the same period. The level of SAA and CRP in three groups were detected and analyzed， ROC was used to analyze. Resluts SAA and CRP in three groups were compared， the difference was statistically significant （P 0.05）. The area under the ROC of SAA and CRP on the diagnosis of MP infection was 0.95 and 0.33， the bacterial infection was 0.88 and 0.86. Conclusion SAA has higher accuracy on the diagnosis of MP and bacterial infection； CRP has higher accuracy on the diagnosis of bacterial infection， it is insignificant for the clinical value of distinguishing and diagnosis the children with MP infection. SAA can be used for distinguishing and diagnosing the children with MP infection and should be extensively used for clinical practice； the clinical value of CRP on diagnosis the children with MP infection still need a deep research. 　　[Key words] Serum amyloid A protein； C-reactive