血清降钙素原与超敏C反应蛋白白细胞计数在儿童急性呼吸道感染中早期诊断价值.docVIP

血清降钙素原与超敏C反应蛋白白细胞计数在儿童急性呼吸道感染中早期诊断价值 　　[摘要] 目的 探究降钙素原（PCT）、超敏C反应蛋白（hs-CRP）与白细胞计数（WBC）在儿童急性呼吸道感染早期诊断中的临床价值。 方法 收集本院收治的145例被确诊为儿童急性呼吸道感染患儿的临床资料（细菌感染组48例，支原体感染组39例，病毒感染组58例），同期健康体检儿童52例为对照组，检测PCT及hs-CRP、WBC的水平并比较其与感染性疾病关系的差异。 结果 细菌性感染组的PCT、WBC指标均显著高于对照组、病毒感染组（P0.01）；比较四组间的hs-CRP指标，差异均有统计学意义（P0.05）；细菌感染组阳性率PCT高于hs-CRP，差异有统计学意义（P0.05）；各组血清PCT与hs-CRP水平呈正相关（r=0.49，P0.05）。 结论 PCT与hs-CRP、WBC的联合监测可以提高儿童急性呼吸道感染早期诊断的准确率，根据结果判断呼吸道感染的严重程度，有助于儿童急性呼吸道感染疾病早期诊断、病情及预后的评估，值得临床推广。 　　[关键词] 血清降钙素原；超敏C反应蛋白；白细胞计数；儿童；急性呼吸道感染 　　[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701（2016）11-0101-03 　　[Abstract] Objective To investigate the clinical value of the serum procalcitonin（PCT） and hypersensitive C-reactive protein（hs-CRP）、WBC in the early diagnosis of acute respiratory infections in children. Methods The clinical data of 145 children diagnosed with acute respiratory infections in our hospital were collected （48 cases of bacterial infections group， 39 cases of mycoplasma infections group， 58 cases of virus infections group）. During the same period， 52 healthy children were selected as control group. The levels of serum PCT and hs-CRP， WBC should be tested and the differences of the relationship with infectious diseases should be compared. Results The indexes of PCT and WBC of the bacterial infections group were significantly higher than those in control group and virus infections group（P0.01）； hs-CRP indexes were compared among the four groups， the differences were significant（P0.05）；Bacterial infections group’s positive rate in PCT was higher than that of hs-CRP， the difference was statistically significant（P0.05）； The serum PCT in each group was positively related to the level of hs-CRP（r=0.49， P0.05）. Conclusion The joint monitoring of PCT and hs-CRP、WBC can improve the accuracy of early diagnosis of acute respiratory infections in children and judging the degree of the severity of respiratory infections according to the results will contribute to the early diagnosis， assesment of severity