血清高敏C反应蛋白脂蛋白a及糖化血红蛋白对2型糖尿病并发冠心病预测价值.docVIP

血清高敏C反应蛋白脂蛋白a及糖化血红蛋白对2型糖尿病并发冠心病预测价值 　　[摘要] 目的 探讨血清高敏C反应蛋白（hsCRP）、脂蛋白a[LP（a）]及糖化血红蛋白（HbA1c）对2型糖尿病（T2DM）并发冠心病（CHD）的早期诊断价值。 方法 选择T2DM患者68例（并发CHD 36例，设为A组；未并发CHD 32例，设为B组），健康志愿者30例为对照（C组）。检测并对比3组的hsCRP、LP（a）和HbA1c水平。 结果 A、B组的血清hsCRP、LP（a）和HbA1c均显著高于C组（P0.05）；A、B组的hsCRP、LP（a）和HbA1c阳性率比较差异有统计学意义（P0.05）；A、B组的单项hsCRP检测阳性率均低于hsCRP+LP（a）+HbA1c，B组的hsCRP+LP（a）+HbA1c联合检测阳性率高于hsCRP+LP（a）（P0.05）。 结论 血清hsCRP+LP（a）+HbA1c联合检测对T2DM并发CHD具有预测价值。 　　[关键词] 2型糖尿病；冠心病；高敏C反应蛋白；脂蛋白a；糖化血红蛋白 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0038-03 　　[Abstract] Objective To investigate the predictive value of high sensitive C-reactive protein（hsCRP），lipoprotein a[LP（a）]and glycosylated hemaoglobin（HbA1c）in type 2 diabetes mellitus（T2DM）complicated with coronary heart disease（CHD）. Methods 68 patients with T2DM（36 patients complicated with CHD and were assigned to group A，32 patients diagnosed simple T2DM were assigned to group B）and 30 healthy volunteers were recruited as group C.HsCRP， LP（a），HbA1c of three groups was detected and compared respectively. Results Serum hsCRP，LP（a） and HbA1c level of group A and B was significantly higher than that of group C respectively（P0.05）.The positive detection rate of hsCRP，LP（a） and HbA1c in group A and B was compared respectively，with statistical difference（P0.05）.The positive rate of three indicators joint detection in group A and B was high than that of single parameter detection（hsCRP）respectively（P0.05）.The positive rate of three indicators joint detection in group B was high than that of hsCRP+LP（a）（P0.05）. Conclusion The joint detection of hsCRP，LP（a） and HbA1c contributes to the early diagnosis of T2DM complicated with CHD. 　　[Key words] Type 2 diabetes；Coronary heart disease；High sensitive C-reactive protein；Lipoprotein a；Glycosylated hemo globin 　　近年来，随着2型糖尿病（type 2 diabetes mellitus，T2DM）发病率的升高，相应的并发症发生率呈上升趋势[1]。资料显示，T2DM并发冠心病（coronary heart disease，CHD）的概率是普通人群的2～4倍，约60%的T2DM患者死于CHD[2-3]。本研究通过对患者血清高敏C反应蛋白（high sensitive C-reactive p