血糖波动对2型糖尿病合并肺癌患者化疗效果影响观察.docVIP

血糖波动对2型糖尿病合并肺癌患者化疗效果影响观察 　　[摘要] 目的 研究血糖波动与2型糖尿病合并肺癌患者化疗效果的相关性。方法 选择该院自2014年4月―2017年4月期间收治的糖尿病合并肺癌患者36例，分组方法依据患者的血糖波动幅度合理划分。将参数正常的患者作为常规组，将血糖波动幅度较高的患者作为研究组，最后对两组患者的各项指标结果进行评定。结果 经调查后可知，比对两组患者的MAGE、空腹血糖、餐后2 h血糖和最大血糖波动幅度，研究组较比常规组更高，组间数据经证实后差异有统计学意义（P0.05）。另外，比对两组患者的癌胚抗原、细胞角蛋白19片段、糖类抗原19-9、糖类抗原153、高敏CRP和肿瘤坏死因子-α参数，研究组较比常规组更高，组间数据经证实后差异有统计学意义（P0.05）。结论 若2型糖尿病合并肺癌患者的血糖波动幅度较高，难以控制肿瘤标志物水平及炎症细胞因子，同时会对化疗效果造成严重影响。 　　[关键词] 血糖波动；2型糖尿病合并肺癌；化疗效果；影响 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 1672-4062（2017）08（b）-0032-02 　　Observation on Effect of Blood Glucose Fluctuation on the Chemotherapy Effect of Patients with Type 2 Diabetics and Lung Cancer 　　YAN Su-hong 　　Department of Oncology Medicine， Shuangyashan Mining Hospital， Shuangyashan， Heilongjiang Province， 155100 China 　　[Abstract] Objective To research the correlation between the blood glucose fluctuation and chemotherapy effect of patients with type 2 diabetics and lung cancer. Methods 36 cases of diabetics and lung cancer patients admitted and treated in our hospital from April 2014 to April 2017 were selected and divided into two groups according to the blood glucose fluctuation range， and the routine group were with the normal parameters， while the research group were the patients with high blood glucose fluctuation range， and various indicators of patients were evaluated finally. Results The investigation showed that the MAGE， fasting blood glucose， postprandial 2h blood glucose and maximum blood glucose fluctuation range in the research group were higher than those in the routine group， and the differences between groups were statistically significant （P0.05）， besides， the carcinoembryonic antigen， cytokeratin 19 fragment， carbohydrate antigen 19-9， carbohydrate antigen 153， high-sensitivity CRP and Tumor necrosis factor-αparameters in the research group were higher than those in the routine group， and the differences were statistically significant（P0.05）. Conclusion The blood glucose fluctuation range of type 2 diabetic