血脂CA153表达异常对乳腺癌转移影响.docVIP

血脂CA153表达异常对乳腺癌转移影响 　　【摘要】 目的：探讨血脂和血CA153异常表达对乳腺癌患者转移的危险因素分析。方法：选取2014年5月-2016年12月本院胸外科收治的118例乳腺癌患者，按照有无远处转移分为远处转移组和非远处转移组，比较两组血脂参数和血CA153的表达差异。结果：血LDLC、TC、TG、CA153在远处转移组表达均高于非远处转移组，差异均有统计学意义（P0.05）。血LDLC、TC、TG与血CA153表达正相关（P0.05）。多元Logistic回归分析显示，高LDLC血症、高TG血症、高TC血症、血CA153升高是乳腺癌发生转移的独立危险因素（OR值分别为6.352、6.986、3.164、2.934、3.092和5.865）。结论：血脂代谢紊乱和血CA153升高与乳腺癌转移的密切相关，乳腺癌患者需要定期监测血脂变化，必要时及时给予调脂治疗。 　　【关键词】 乳腺癌； 转移； 血脂； 血CA153 　　Effect of Abnormal Expression of Blood Lipid and CA153 on Metastasis of Breast Cancer/WANG Dongmei，LEI Xianhua，LI Rong，et al.//Medical Innovation of China，2017，14（32）：054-057 　　【Abstract】 Objective：To investigate the risk factor of abnormal expressions of blood lipid and CA153 on metastasis of breast cancer patients.Method：A total of 118 subjects with breast cancer in Thoracic Surgery Department of our hospital from May 2014 to December 2016 were divided into distant metastasis group and non-distant metastasis group，and the differences in lipid index and CA153 expressions of two groups were compared.Result：The expressions of LDLC，TC，TG and CA153 in distant metastasis group were higher than those of non-distant metastasis group，and the differences were statistically significant（P0.05）.Positive correlations were observed between LDLC，TC，TG and CA153（P0.05）.By multiple Logistic regression analysis，elevated levels of LDLC，TG，TC and CA153 were independent risk factors for metastasis of breast cancer（OR values were 6.352，6.986，3.164，2.934，3.092 and 5.865）.Conclusion：Lipid metabolism disorder is closely related to CA153 elevation.Regular monitoring of blood lipid is suggested to breast cancer patients，and lipid lowering therapy when necessary. 　　【Key words】 Breast cancer； Metastasis； Blood lipid； CA153 　　First-author’s address：Ganzhou Tumor Hospital，Ganzhou 341000，China 　　doi：10.3969/j.issn.1674-4985.2017.32.013 　　乳腺癌是女性常?恶性肿瘤之一，近年来随着我国生活水平的提高，生活方式西化，乳腺癌发病人数和死亡人数逐年上升，且约10%患者发现时已经达中晚期[1-2]。既往研究证实脂类代谢异常影响乳腺癌的发生，而目前有研究发现血脂异常可能与乳腺癌转移有关[3]。本研究通过观察乳腺癌患者血脂