藏成药如意珍宝丸对缺血性脑卒中大鼠亚急性期干预作用.docVIP

藏成药如意珍宝丸对缺血性脑卒中大鼠亚急性期干预作用 　　[摘要]缺血性脑卒中是全球导致死亡及长期致残的主要原因，是由于脑部供血障碍引起脑组织相应区域缺血、低氧，致使脑血管功能障碍出现一系列生化代谢失常、生理功能丧失的疾病，其高致残率给社会、政府和家庭带来了巨大的负担，但目前尚缺少理想的治疗药物。该文在建立大鼠右侧大脑中动脉阻塞模型基础上，从减轻神经元尼氏小体损伤、降低脑水肿及炎症反应、阻止细胞凋亡等方面着手，观察藏成药如意珍宝丸多途径、多方位的干预作用，为探讨该药对缺血性脑卒中的疗效机制奠定重要研究基础。 　　[关键词]如意珍宝丸;脑卒中;大脑中动脉阻塞;尼氏小体;凋亡 　　[收稿日期]2014-05-09 　　[基金项目]国家自然科学基金面上项目;国家“重大新药创制”科技重大专项（2013Z014） 　　[通信作者]*谭睿，教授，Tel：（028E-mail：tanrui@ 　　[作者简介]刘睿颖，讲师，研究方向为心脑血管药理，Tel：（028E-mail：liuruiying1979@126.comIntervention effect of Tibetan patent medicine Ruyi Zhenbao pills 　　in acute ischemic stroke in rats 　　LIU Rui-ying1， WU Wei-jie1， TAN Rui1*， XIE Bin1， ZHONG Zhen-dong2， HE Jing-ping1， CHEN Yao1， KANG Xin-li1 　　（1. College of Life Science and Engineering， South-West Jao Tong University， Chengdu 610031， China; 　　2. Pathological Department， Sichuan Provincial People′s Hospital， Chengdu 610072， China） 　　[Abstract]Ischemic stroke is a primary cause of death and long-term disability all over the world. This disease is resulted from ischemia and hypoxia in brain tissues because of insufficient blood supply and causes a series of physiochemical metabolism disorders and physiological dysfunction. Its high disability ratio has bright huge burdens to society， governments and families. However， there is not efficacious medicine to treat it. In this study， a right middle cerebral artery occlusion was established in rats to observe the multi-path and multi-aspect intervention effects of Tibetan patent medicine Ruyi Zhenbao pills in reducing injuries to Nissl bodies， cerebral edema and inflammatory reactions and preventing cellular apoptosis， in order to lay a foundation for defining its therapeutic mechanism in acute ischemic stroke. 　　[Key words]Ruyi Zhenbao pills; stroke; cerebral artery occlusion; Nissl bodies; apoptosis 　　doi：10.4268/cjcm 　　传统中医观念认为，中风或称缺血性脑卒中，属于“筋失所养，经络阻滞”lt;supgt;[1]lt;/supgt;，如意珍宝丸由珍珠母、香旱芹、荜茇、毛诃子、藏木香等30味药材组成，具有清热，醒脑开窍，舒筋通络的作用，是藏医用来治疗神经经络疾病的首选药