丁苯酞注射液在颈内动脉狭窄患者介入治疗围手术期应用的研究-神经病学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要 ·············································································1 英文摘要 ·············································································2 英文缩写 ·············································································4 研究论文 丁苯酞注射液在颈内动脉狭窄患者介入治疗围手术期应用 的研究 前言 ·············································································5 材料与方法 ····································································8 结果 ·············································································12 附图 ·············································································14 附表 ·············································································16 讨论 ·············································································19 结论 ·············································································26 参考文献 ·······································································27 综述 丁苯酞氯化钠注射液对颈内动脉狭窄患者的治疗作用 ·············31 致谢 ···················································································49 个人简历 ·············································································50 PAGE 1万方数据 PAGE 1 万方数据 中 文 摘 要 丁苯酞注射液在颈内动脉狭窄患者介入治疗 围手术期应用的研究 摘 要 目的：探讨丁苯酞氯化钠注射液在颈内动脉狭窄患者介入治疗围手术 期的临床疗效及其安全性? 方法：选取 80 例介入治疗的颈内动脉狭窄患者，随机分为治疗组及 对照组各 40 例；两组均给予常规治疗阿司匹林肠溶片 100mg 日一次，氯 吡格雷 75mg 日一次，立普妥 20mg 日一次，而治疗组，基于对照组基础 之上加用丁苯酞氯化钠注射液 100ml 日二次，疗程为 14 天。两组进行治 疗的时间为两周?两组在治疗前及治疗后记录脑血容量(cerebral blood volume,CBV)?脑血流量(cerebral blood flow,CBF) ?平均通过时间(mean transit time,MTT)及达峰时间(time to peak,TTP)参数，进行神经功能缺损程 度评分?并通过 SPSS19.0 进行统计，所得到的结果再利用 t 进行检验，对 每个变量之间所存在的差异进行统计，观察有无统计学意义? 结果：与对照组相比，不仅治疗后神经功能缺损程度评分治疗组明显 低于对照组，差异有统计学意义（P＜0.05），而且治疗后脑血容量(cerebral blood volume，CBV)、脑血流量(cerebral blood flow，CBF)、平均通过时 间(mean transit time，MTT)及达峰时间(time to peak，TTP)参数差异有统 计学意义（P＜0.05）。 结论：丁苯酞氯化钠注射液是一类新型脑保护药物，具有抗缺血作用， 对颈内动脉狭窄患者介入围手术期的治疗安全有效。 关键词：丁苯酞氯化钠注射液，脑梗死，颈内动脉狭窄，介入治疗， 神经功能缺损程度，围手术期，临床疗效，安全性 英 英 文 摘 要 Th