连续性肾脏替代疗法在重症急性胰腺炎相关性肾损害治疗中应用分析.docVIP

连续性肾脏替代疗法在重症急性胰腺炎相关性肾损害治疗中应用分析 　　[摘要] 目的 回顾性分析连续性肾脏替代疗法（continuous renal replacement therapy，CRRT）对重症急性胰腺炎相关性肾损害实施治疗的临床效果。 方法 收集我科收治的重症急性胰腺炎相关性肾损害疾病患者，按治疗方式不同分为常规组和连续性肾脏替代疗法组，常规组采用常规急性肾损伤治疗方案，连续性肾脏替代疗法组在常规方案基础上加用连续性肾脏替代疗法。比较两组患者治疗前后肾功能相关指标的变化情况，记录两组患者肾功能恢复所需时间以及临床治疗效果。 结果 连续性肾脏替代疗法组患者在治疗前后肾功能相关指标水平的改善幅度明显大于常规组，差异有统计学意义（P0.05）；重症急性胰腺炎相关性肾损害疾病治疗总有效率为91.7%，明显优于常规组的66.7%，差异具有统计学意义（P0.05）；肾功能相关指标恢复正常时间和肾损伤疾病治疗方案实施总时间少于常规组，差异具有统计学意义（P0.05）。 结论 采用连续性肾脏替代疗法对重症急性胰腺炎相关性肾损害具有显著的临床效果。 　　[关键词] 重症急性胰腺炎；急性肾损伤；连续性肾脏替代疗法 　　[中图分类号] R576 [文献标识码] B [文章编号] 1673-9701（2016）21-0086-03 　　[Abstract] Objective To retrospectively analyze the clinical curative effects of continuous renal replacement therapy （CRRT） in the treatment of severe acute pancreatitis induced renal impairment. Methods Patients with severe acute pancreatitis induced renal impairment who were admitted to our department were collected. They were assigned to the regular group and CRRT group according to different treatment approaches. The regular group was given the regular treatment protocol of acute renal impairment， and the CRRT group was given CRRT on the basis of the regular group. Changes of relevant indicators of renal function were compared before and after the treatment in both groups， and the time required for the recovery of renal function in both groups as well as clinical curative effects were recorded. Results The improvement degree of renal function-related indicators in the patients in CRRT group before and after the treatment was significantly higher than that in the regular group； the total curative effect of severe acute pancreatitis induced renal impairment was 91.7%， which was significantly better than that of 66.7% in the regular group， with significant difference（P0.05）； time of renal function-related indicators resuming to normal and total time of implementing the treatment protocol of renal impairment was shorter than that in the regular group， with significant difference（P0.05）. Conclusion CRR