软坚散结方联合辛伐他汀治疗颈动脉粥样硬化临床研究.docVIP

软坚散结方联合辛伐他汀治疗颈动脉粥样硬化临床研究 　　[摘要]目的 分析软坚散结方联合辛伐他汀治疗颈动脉粥样硬化的临床应用效果。 方法 选择2012年7月～2014年7月在本院接受住院治疗的颈动脉粥样硬化患者100例作为研究对象，按照随机数字表法将所有入组患者分为观察组（50例）接受软坚散结方联合辛伐他汀治疗，对照组（50例）接受单纯辛伐他汀治疗，比较两组患者的血脂水平、内皮细胞功能、颈动脉IMT及内膜斑块厚度等水平差异。 结果 观察组患者接受治疗后的TC、TG、LDL水平低于对照组，HDL水平高于对照组患者（P0.05）；观察组患者接受治疗后的EMCs水平低于对照组、FMD水平高于对照组患者（P0.05）；观察组患者接受治疗后的颈动脉IMT及内膜斑块厚度水平均低于对照组患者（P0.05）。 结论 软坚散结方联合辛伐他汀可以有效降低颈动脉粥样硬化患者血脂水平、颈动脉IMT及内膜斑块厚度，优化内皮细胞功能。 　　[关键词]动脉粥样硬化；软坚散结方；辛伐他汀 　　[中图分类号] R543.5 [文献标识码] A [文章编号] 2095-0616（2015）16-22-04 　　Clinical research of curative effect of Ruan Jian San Jie Fang （Softening Hard Nodes or Masses Prescription） combined with simvastatin in the treatment of carotid atherosclerosis 　　CHEN Xiaoyun CHEN Chunying BAI Haibo 　　First Department of Internal Medicine， Yunfu Hospital of Traditional Chinese Medicine， Yunfu 527300， China 　　[Abstract]Objective To analyze the clinical application effect of Ruan Jian San Jie Fang combined with simvastatin in the treatment of carotid atherosclerosis. Methods 100 patients with carotid atherosclerosis who were admitted to our hospital and hospitalized from July 2012 to July 2014 were selected as research subjects. They were allocated to observation group and control group with 50 patients in each according to the random number table method. The observation group received the treatment of decoction of herbs aiming at softening hard nodes or masses combined with simvastatin while the control group only received simvastatin. Blood lipid level， endothelial function， carotid IMT， the thickness of intimal plaque， etc of the two groups were compared. Results Levels of TC， TG， LDL after the treatment in the observation group were lower than those in the control group while the level of HDL level after the treatment was higher than that of control group（P0.05）； EMCs level after the treatment in the observation group was lower than that in the control group while the FMD level after the treatment was higher than that in the control group； After the tre