通心络联合曲美他嗪对急性ST段抬高型心肌梗死经皮冠状动脉介入治疗术后患者血脂及心功能影响.docVIP

通心络联合曲美他嗪对急性ST段抬高型心肌梗死经皮冠状动脉介入治疗术后患者血脂及心功能影响 　　 　　[摘要] 目的 研究通心络联合曲美他嗪对急性ST段抬高型心肌梗死（STEMI）经皮冠状动脉介入治疗（PCI）后患者血脂及心功能的影响。 方法 选择2011年5月～2013年5月三河市医院心内科160例STEMI PCI术后患者，按照随机数字表法分成治疗组和对照组，各80例。对照组常规应用拜阿司匹林、硫酸氢氯吡格雷、硝酸异山梨酯、酒石酸美托洛尔、卡托普利、利尿剂、阿托伐他汀；治疗组在对照组基础上加用通心络胶囊、盐酸曲美他嗪，疗程12周。观察两组患者治疗前后总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及左心室射血分数（LVEF）、左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）变化。 结果 两组治疗后TC、TG、LDL-C及HDL-C水平与治疗前比较差异有统计学意义（P ＜ 0.05）；治疗组血脂变化水平显著优于对照组（P ＜ 0.05）。两组患者治疗后LVEF升高，LVEDV、LVESV下降，与治疗前比较，差异有统计学意义（P ＜ 0.05），但治疗组LVEF、LVEDV、LVESV指标较对照组变化更显著，差异有统计学意义（P ＜ 0.05）。 结论 通心络联合曲美他嗪对STEMI PCI术后患者血脂及心功能的改善效果明显，能显著提高患者生存质量。 　　[关键词] 通心络；曲美他嗪；血脂；心功能 　　[中图分类号] R541.5[文献标识码] A[文章编号] 1673-7210（2014）05（b）-0066-04 　　 　　Effects on serum lipid and cardiac function of Tongxinluo combined with Trimetazidine in the treatment of patients with acute ST-elevation myocardial infarction after underwent percutaneous coronary intervention 　　ZHOU Shuting1 XIAO Chunyue2▲ GUO Ruimin3 　　1.Department of Cardiology, Sanhe City Hospital, Hebei Province, Sanhe 065200, China; 2.Department of Neurology, Sanhe City Hospital, Hebei Province, Sanhe 065200, China; 3.Department of Laboratory Medicine, Sanhe City Hospital, Hebei Province, Sanhe 065200, China 　　[Abstract] Objective To investigate the effect on serum lipid and cardiac function of Tongxinluo combined with Trimetazidine in the treatment of patients with acute ST-elevation myocardial infarction (STEMI) after underwent percutaneous coronary intervention (PCI). Methods 160 patients with STEMI after underwent PCI in Department of Cardiology of Sanhe City Hospital from May 2011 to May 2013 were chosen and divided into treatment group and control group according to random number table method, with 80 patients in each group. Control group was routinely given Aspirin, Clopidogrel Hydrogen Sulfate, Isosorbide Dinitrate, Metoprolol Tartrate, Captopril, diuretics and Atorvastatin, treatment group was added with Tongxinluo Capsule and Trimetazidine on