降钙素原与C反应蛋白检测在新生儿病理性黄疸中临床意义.docVIP

降钙素原与C反应蛋白检测在新生儿病理性黄疸中临床意义 　　[摘要] 目的 探讨降钙素原（PCT）及C反应蛋白（CRP）在新生儿病理性黄疸病因分析中的应用价值。 方法 对2011 年6月～2013 年3月在我院新生儿科住院的诊断为新生儿病理性黄疸83例临床资料进行回顾性分析。根据病因及实验室检查结果分为感染组及非感染组，分析两组血清中PCT、CRP水平变化。 结果 新生儿黄疸感染组PCT及CRP均明显高于非感染组，差异有统计学意义（P0.05）。PCT敏感性为92.0%，特异性87.9%，CRP敏感性为68.0%，特异性63.8%，对细菌感染的诊断PCT比CRP具有更高的敏感性及特异性。 结论 血清PCT检测优于血清CRP检测，可用于新生儿病理性黄疸细菌感染的诊断依据，对指导临床合理应用抗生素有重要意义。 　　[关键词] 降钙素原；C反应蛋白；新生儿黄疸 　　[中图分类号] R446 [文献标识码] B [文章编号] 2095-0616（2013）15-209-03 　　Clinical significance of procalcitonin and C-reactive protein in the assay of newborn pathological jaundice 　　LIANG Yanqing XING Zijun CHEN Ruifang 　　Department of Neonatology， Haizhu Maternal and Child Health Hospital， Guangzhou 510420， China 　　[Abstract] Objective To investigate the application value of procalcitonin and C-reactive protein in the etiological analysis of newborn pathological jaundice. Methods 83 casess clinical datum of newborn pathological jaundice in the neonatology department from June 2011 to March 2013 were selected and retrospectively analyzed. They were divided into infection group and non-infection group according to the etiology and laboratory test results， analyzed the changes of serum PCT， CRP levels in the two groups. Results the PCT， CRP levels in the newborn jaundice infection group were significantly higher than those in the non-infected group， P0.05， there had statistically significant difference. PCT sensitivity was 92.0%， specificity was 87.9%； CRP sensitivity was 68.0%， specificity was 63.8%， PCT had higher sensitivity and specificity than CRD in the diagnosis of bacterial infection. Conclusion Serum PCT test is superior to serum CRP test， it can be used for bacterial infections diagnosis in newborn pathological jaundice. It has important significance for clinical rational use of antibiotics. 　　[Key words] Procalcitonin； C-reactive protein； Newborn jaundice 　　新生儿黄疸是因胆红素在体内积聚引起的皮肤或其他器官黄染，分生理性及病理性[1]。病理性黄疸病因较多，常见有：感染、围生期窒息、溶血、母乳性黄疸、先天性胆道畸形等，其中感染引起的溶血在临床中不少见。而新生儿败血症早期往往症状不典型，以黄疸为首发症状的败血症屡见不