间苯三酚在0.9%氯化钠注射液中稳定性与效价探究.docVIP

间苯三酚在0.9%氯化钠注射液中稳定性与效价探究 　　[摘要] 目的 探究间苯三酚在0.9%氯化钠注射液中的稳定性与效价。 方法 2017年5―9月在该院药学部用高效液相色谱法测定注射用间苯三酚与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍后间苯三酚在不同时间点效价变化，同时观察其配伍液外观、颜色与pH值变化状况。 结果 经检测发现，①5%葡萄糖注射液在室温下放置3 h效价为99.87%、6 h效价为99.61%，10%葡萄糖注射液室温下放置3 h效价为99.12%、6 h效价为100.06%，0.9%氯化钠注射液室温下放置3 h效价为100.84%、6 h效价为100.12%，，组间比较差异无统计学意义（P0.05）；②3种配伍液在室温下放置0、3、6 h后的pH值变化均集中在0.05～0.12范围内，且配伍液未见有外观、颜色和可见异物的变化。 结论 间苯三酚在0.9%氯化钠注射液中具有较高的生物学效价与良好的稳定性，且其效果与5%葡萄糖注射液、10%葡萄糖注射液类似。因此，在临床上对于糖尿病等其他特殊病情者，可使用0.9%氯化钠注射液作为间苯三酚的稀释溶媒。 　　[关键词] 间苯三酚；0.9%氯化钠注射液；稳定性；效价 　　[中图分类号] R969 [文献标识码] A [文章编号] 1674-0742（2018）03（b）-0117-03 　　Study on Stability and Titer of Phloroglucinol in the 0.9% Sodium Chloride Injection 　　DAI Mei-fen1， WANG Shi-yun2 　　1.Liquor Room， Drug and Equipment Department， Qujing First Peoples Hospital， Qujing， Yunnan Province， 655000 China；2.Drug and Equipment Department， Qujing First Peoples Hospital， Qujing， Yunnan Province， 655000 China 　　[Abstract] Objective To study the stability and titer of phloroglucinol in the 0.9% sodium chloride injection. Methods The changes of phloroglucinol combined with 0.9% sodium chloride injection， 5% glucose injection and 10% glucose injection at different time points were measured by the high-performance liquid chromatography in the department of pharmacy in our hospital from May 2017 to September 2017， at the same time， the appearance of compatibility infusion， color and pH value changes were observed. Results The test showed that titers at 3 h and 6 h of 5% glucose injection， 10% glucose injection and 0.9% glucose injection at the room temperature were respectively 99.87% and 99.61%， 99.12% and 100.06%， 100.84% and 100.12%， and the differences were not statistically significant（P0.05）， and the pH changes at 0h，3h，6h of the three solutions at the room temperature concentrated between 0.05 and 0.12， and there were no changes of appearance， color and visible particles. Conclusion The biology titer and stability of phloroglucinol in the 0.9% sodium ch