钙黏附素和β连接素在子宫颈上皮内瘤变表达及意义.docVIP

钙黏附素和β连接素在子宫颈上皮内瘤变表达及意义 　　[摘要] 目的：观察钙黏附素（E-cad）和β-连接素（β-cat）在宫颈上皮内瘤变组织中的表达，探讨其与宫颈上皮内瘤变进展的关系。方法：采用免疫组化法检测51例宫颈组织病理存档石蜡包埋组织钙黏附素和β-连接素的表达。结果：E-cad在柱状上皮移位组织、各级CIN组织中的阳性表达率分别为80.0%、66.7%和55.6%、42.9%，即从柱状上皮移位→CINⅠ级→CINⅡ级→CINⅢ级，E-cad的表达阳性率呈递减趋势，其差异有统计学意义（P0.05）；β-catenin在柱状上皮移位组织、CIN各级组织中的阳性表达率分别为90.0%、77.8%和61.1%、50.0%，即从柱状上皮移位→CINⅠ级→CINⅡ级→CINⅢ级，E-cad的表达阳性率呈递减趋势，其差异有统计学意义（P0.05）。结论：钙黏附素、β-连接素与宫颈上皮内瘤变的进展相关，在估计CIN的预后中有一定意义。 　　[关键词] 钙黏附素；β-连接素；宫颈上皮内瘤变；宫颈肿瘤；免疫组化 　　[中图分类号] R737.33 [文献标识码]A[文章编号]1674-4721（2011）04（b）-038-02 　　 　　Expression and the significance of E-cadherin and β-catenin in cervical intraepithelial neoplasia 　　ZHANG Juanjuan1, CHEN Yongping2, ZHANG Tianfeng1, WU Xiuxia1 　　1.Minimally Invasive Gynecological Treatment Center, the Fifth People′s Hospital of Shenzhen City, Guangdong Province, Shenzhen 518001, China; 2.Department of Pathology, the Fifth People′s Hospital of Shenzhen City, Guangdong Province, Shenzhen 518001, China 　　[Abstract] Objective: To investigate the expression and the significance of E-cadherin and β-catenin in cervical intraepithelial neoplasia. Methods: E-cadherin and β-cateninexpressions in 51 cases of CIN and columnar ectopy was detected by immunohistochemistry method. Results: The positive rates of E-cadherin in the columnar ectopy group, CINⅠ group, CIN Ⅱ group and CIN Ⅲ group were 80.0%，66.7%，55.6%, 42.9%, respectively. There was significant statistical difference (P0.05). With the development of cervical lesion，the expressions of E-cadherin was decreasing; the positive rates of β-catenin in the columnar ectopy group, CINⅠ group, CIN Ⅱ group and CIN Ⅲ group were 90.0%, 77.8%, 61.1%, 50.0%, respectively. There was significant statistical difference (P0.05). With the development of cervical lesion, the expressions of E-cadherin was decreasing. Conclusion: The results indicate that decreased E-cadherin and β-catenin expression might be a useful marker for diagnosis of cervical carcinoma and a effectively tool for predicting the m