银杏叶注射液治疗急性脑梗死随机对照试验系统评价.docVIP

银杏叶注射液治疗急性脑梗死随机对照试验系统评价 　　[摘要] 目的 评价银杏叶提取物注射液治疗急性脑梗死随机对照试验的临床有效性和安全性。 方法 采用电子检索途径收集银杏叶注射液治疗急性脑梗死的随机对照试验，共纳入15项研究，共计1671例患者，采用RevMan4.2.2软件进行Meta分析。 结果 近期有效率：银杏叶提取物组与丹参注射液比较（OR合并=3.34，95%CI=2.28～4.88），与曲克芦丁注射液（OR合并=3.22，95%CI=1.72～6.04）及常规治疗组（OR合并=5.07；95%CI=2.75～9.37）比较，多个RCT的综合结果即森林图显示银杏叶提取物注射液组治疗脑梗死更有效。神经功能缺损评分加权均数差值为-3.83（95%CI为-4.36～-3.29）。 结论 银杏叶提取物注射液治疗急性脑梗死的随机对照试验显示其更有效，但所用的方法学质量均较低，样本量均偏小，存在发表偏倚，尚需进行高质量、大样本量的随机对照试验予以进一步证实。 　　[关键词] 银杏叶注射液；急性脑梗死；随机对照试验；系统评价；Meta分析 　　[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721（2015）02（b）-0004-06 　　Systematic review on random controlled trial of Ginkgo biloba extract injection in the treatment of acute cerebral infarction 　　XU Jun-ying1 XU Li2 　　1.Department of Neurology，the Third Division Hospital of Xinjiang Production and Construction Corps，Kashi 844000，China；2.Department of Hematology，the First People′s Hospital of Kashi Area in the Xinjiang Uygur Autonomous Region，Kashi 844000，China 　　[Abstract] Objective To assess the clinical efficacy and safety on Ginkgo biloba extract injection in the treatment of acute cerebral infarction. Methods Randomized controlled trial of Ginkgo biloba extract injection in the treatment of acute cerebral infarction was collected by electronic retrieval.15 studies and a total of 1671 patients were listed.The RevMan4.2.2 was used in data Meta analysis. Results The recent efficiency：Ginkgo biloba extract group and Danshen injection combined with comparison（Peto-OR was 3.34，95%CI was from 2.28 to 4.88），Troxerutin injection（Peto-OR was 3.22，95%CI was from 1.72 to 6.04）and conventional treatment group（Peto-OR was 5.07，95%CI was from 2.75 to 9.37）.Multiple RCT forest graph result showed that the treatment of cerebral infarction，Ginkgo biloba extract group more effectively.The nerve function deficit score therapy weighted mean difference value of -3.83（95%CI was from -4.36 to -3.29）. Conclusion The evidence currently available shows that Ginkgo biloba extract injection is more effective.But the qua