降钙素与C反应蛋白联合检测在新生儿败血症诊断中应用.docVIP

降钙素与C反应蛋白联合检测在新生儿败血症诊断中应用 　　[摘要] 目的 探讨降钙素（PCT）与C-反应蛋白（CRP）联合检测在新生儿败血症诊断中的临床应用价值。 方法 选取2011年1月～2012年12月来本院进行诊治的新生儿败血症患儿80例作为检测组，检测组患儿均进行PCT与CRP水平检测，同时，选取80例正常新生儿作为对照组，分析比较两组的PCT与CRP水平。 结果 检测组患儿的PCT与CRP水平均明显高于对照组患儿（P 0.05）；两组新生儿PCT、CRP检测阳性率比较，差异有统计学意义（P 0.05）。 结论 临床对新生儿败血症患儿行PCT与CRP联合检测，可有助于新生儿败血症的早期诊断和疗效观察，对病情的及时治疗和预后评估具有一定的临床应用价值，值得临床广泛应用及推广。 　　[关键词] 新生儿败血症；降钙素；C-反应蛋白；临床应用 　　[中图分类号] R446.11 [文献标识码] C [文章编号] 1674-4721（2013）07（a）-0084-02 　　Application of procalcitonin and C-reactive protein joint detection in diagnosis of neonatal sepsis 　　PAN Shao-xia LIU Shou-ming LIANG Miao-zhi 　　Department of Clinical Laboratory，TCM Hospital of Qingyuan City in Guangdong Province，Qingyuan 511500，China 　　[Abstract] Objective To investigate the value of clinical application of procalcitonin （PCT） and C-reactive protein （CRP） joint detection in diagnosis of neonatal sepsis.Methods Eighty newborn with neonatal sepsis diagnosed and treated in our hospital from January 2011 to December 2012 were selected as detection group and detected for levels of PCT and CRP.Eighty normal newborn were simultaneously selected as control group.The levels of PCT and CRP in both groups were respectively compared.Results Levels of PCT and CRP in detection group were significantly higher than those in control group （P 0.05）.The comparison of positive rate of PCT and CRP detection in both groups showed statistically significant difference （P 0.05）.Conclusion Clinical joint detection of PCT and CRP for newborn with neonatal sepsis can contribute to early diagnosis and observing therapeutic effectiveness of neonatal sepsis，has certain value of clinical application in timely treating and prognosis accessing，and is worth widely clinical applying and promotion. 　　[Key words] Neonatal sepsis；Procalcitonin；C-reactive protein；Clinical application 　　新生儿败血症是临床常见的一类新生儿血液系统疾病，其致病原因较为复杂，主要是由于细菌通过各种方式侵入婴儿血液系统进行生长繁殖，产生毒素从而发生全身性细菌感染[1]。临床表现主要有不吃奶、哭声减弱、发热、贫血、黄疸、皮肤出血、腹胀、抽搐等。由于症状不明显，临床常用的快速灵敏诊断方法较少，给早期诊断造成一定的困难，