高压氧早期治疗对高血压脑出血患者术后神经功能及血清hs―CRP影响.docVIP

高压氧早期治疗对高血压脑出血患者术后神经功能及血清hs―CRP影响 　　【摘要】 目的：探讨高压氧早期治疗对高血压脑出血（HICH）患者术后神经功能恢复及血清hs-CRP水平的影响。方法：将78例HICH患者按照随机数字表法分为高压氧组（42例）和对照组（36例）。对照组给予开颅血肿清除手术、控制血压、脱水降颅压和营养神经等常规治疗，高压氧组在对照组的基础上于术后第5天开始高压氧治疗，1次/d，共20 d。观察两组患者的治疗有效率和入院时、手术后第5天及高压氧20 d后脑水肿程度、血清hs-CRP水平及两者之间的相关性。结果：高压氧组患者治疗后治疗有效率较对照组明显提高（P0.05）；治疗后高压氧组和对照组脑水肿体积和血清hs-CRP水平均较治疗前均明显降低（P0.05），而高压氧组脑水肿体积和血清hs-CRP减少程度均显著高于对照组（P0.05）；Pearson相关分析显示，HICH患者血清hs-CRP水平与脑水肿程度之间呈显著正相关（P0.05）。结论：高压氧早期治疗能显著促进HICH患者神经功能的恢复，减轻患者脑水肿程度及降低血清hs-CRP水平。 　　【关键词】 高血压脑出血； 高压氧； 治疗效果； 超敏C反应蛋白 　　Effect of Hyperbaric Oxygen Treatment on Neurological Function and Serum hs-CRP in Patients with Hypertensive Intracerebral Hemorrhage/SHAO Junqing，CHEN Xiaofei，LI Yi，et al.//Medical Innovation of China，2017，14（35）：067-070 　　【Abstract】 Objective：To observe the effect of hyperbaric oxygen （HBO） treatment applied to patients with hypertensive intracerebral hemorrhage（HICH） on neurological function and serum hypersensitive C-reactive protein（hs-CRP）.Method：Seventy-eight patients with HICH were randomly divided into HBO treatment group（n=42） and the control group（n=36）.The control group was treated with conventional treatment，including craniotomy，blood pressure control，dehydration to reduce intracranial pressure and nerves nutrition.On the basis of the control group，HBO treatment group was treated with HBO therapy at the fifth day after craniotomy and lasted 20 d.The curative effects and serum hs-CRP were compared between two groups before and after treatment.Result：After treatment，the curative effects of HBO treatment group were significantly higher than those of the control group（P0.05）.Compared with before treatment，cerebral edema volume and serum hs-CRP level of two groups were obviously reduced after treatment（P0.05），and there were statistically significant differences between two groups after treatment（P0.05）.Additionally，there were significant positive correlation between cerebral edema volume and serum hs-CRP levels（P0.05）.Conclusion：Early treat