亚胺培南―西司他丁钠30min与3h输注给药治疗重症肺炎对照研究.docVIP

亚胺培南―西司他丁钠30min与3h输注给药治疗重症肺炎对照研究 　　[摘要] 目的 探讨亚胺培南-西司他丁钠30 min和3 h输注给药治疗重症肺炎的临床疗效。 方法 选择2014年6月～2015年6月在我院接受亚胺培南-西司他丁钠治疗的重症肺炎患者60例，随机分为研究组和对照组，对照组患者输注30 min，研究组患者输注3 h，对比两组患者重症监护时间、机械通气时间、湿??音基本消失时间、咳嗽、咳痰基本消失时间，记录治疗前后白细胞计数、PaO2、PaO2/FiO2的变化情况，并统计两组患者治疗有效率、28 d生存率及细菌清除率。 结果 研究组患者重症监护时间为（117.75±1.01）h、机械通气时间为（92.09±4.23）h、湿??音基本消失时间为（9.65±1.21）d、咳嗽基本消失时间为（8.71±1.08）d，均显著优于对照组，差异有统计学意义（P0.05）；研究组患者治疗后白细胞计数（7.02±1.41）×109/L、PaO2（85.01±1.26） mmHg、PaO2/FiO2（296.58±5.96）均显著优于对照组，同时研究组患者治疗有效率为90.00%、28 d生存率为93.33%及细菌清除率为86.67%，均显著优于对照组，差异有统计学意义（P0.05）。 结论 亚胺培南-西司他丁钠3 h输注给药治疗重症肺炎能显著改善肺功能，清除细菌，提高治疗效率。 　　[关键词] 亚胺培南-西司他丁钠；输注时间；重症肺炎；细菌清除率 　　[中图分类号] R563.1 [文献标识码] B [文章编号] 1673-9701（2015）32-0105-03 　　[Abstract] Objective To investigate clinical efficacy of the imipenem-cilastatin sodium in treating severe pneumonia by infusion therapy for 30 minutes and three hours. Methods 60 patients with severe pneumonia who received imipenem -cilastatin sodium therapy from June 2014 to June 2015 in our hospital， were chosen and randomLy divided into the study group and the control group. Patients in the control group received infusion therapy for 30 minutes， and patients in the study group received infusion therapy for 3 hours. Intensive care time， mechanical ventilation time， auscultation disappeared time， cough and expectoration disappeared time of patients in the two groups were compared， and leukocyte count， changes of PaO2 and PaO2/FiO2 before and after treatment were recorded， and efficiency rate of patients in the two groups， 28-day survival rate and bacterial eradication rate were counted. Results The intensive care time of patients in the study group was （117.75±1.01） hours， and mechanical ventilation time was（92.09±4.23） hours. Auscultation disappeared time in the study group was （9.65±1.21） days， and cough disappeared time was （8.71±1.08） days. Those in the study group were significantly better than those in the control group， and the difference was statistically significant （P