高血压肾病患者转化生长因子β1表达及临床意义.docVIP

高血压肾病患者转化生长因子β1表达及临床意义 　　[摘要] 目的 该研究旨在探讨TGF-β1水平对原发性高血压肾病的早期诊断价值。方法 方便选取2010年6月―2016年6月在该院接受治疗的确诊为高血压肾病的成年患者82例作为实验组，选择同期入院的65名健康者作为对照组，比较分析两组患者的血清TGF-β1的水平、尿mAlb含量及eGFR，并分析其相关性。结果 高血压肾病组血浆TGF-β1（46.6±12.8）ug/L、尿微量白蛋白（mAlb）（18.0±4.2） mg/L水平显著高于正常对照组，而肾小球滤过率估计值（eGFR）（50.7±12.5）mL/（min?1.73 m2）显著低于对照组。高血压肾病组TGF-β1、mAlb与eGFR相比较均具有极为显著的负相关（r2=0.9779）；而对照组TGF-β1、mAlb与eGFR之间无显著的关联性（r2=0.6762）。结论 高血压肾病的病理改变伴随着一个复杂的包含血管损伤与修复的病理性血管重塑过程。高血压肾病的发病机制可能与TGF-β1/Smad 信号转导功能的增强有关。 　　[关键词] 高血压肾病；生长因子；肾小球滤过率 　　[中图分类号] R697 [文献标识码] A [文章编号] 1674-0742（2016）12（b）-0014-03 　　Clinical Significance of TGF-β1 Expressions in Hypertensive Nephropathy 　　YUAN Shou-ping 　　Department of Renal Medicine， Putian First Hospital， Fujian Province， Putian， Fujian Province， 351100 China 　　[Abstract] Objective The aim of the present study is to explore the potential values for the early diagnosis of primary hypertensive nephropathy. Methods Convenient selection adult patients with hypertensive nephropathy who were treated in our hospital from June 2010 to June 2016 were diagnosed as experimental group. The experimental group consisted of 82 consecutive adult hypertensive nephropathy patients. Sixty five healthy controls were enrolled in this study. The levels of serum TGF-β1， urinary mAlb and eGFR in the two groups were compared and analyzed， and the correlations were analyzed between the two groups. Results The plasma TGF-β1（46.6±12.8）μg/L and microalbuminuria （mAlb） （18.0±4.2）mg/L in the urine were significantly higher and the estimated glomerular filtration rate （eGFR） （50.7±12.5）mL/（min?1.73 m2）was significantly lower in the Hypertensive Nephropathy Group than in the Control. In the Hypertensive Nephropathy Group， TGF-β1 and mAlb showed a significant correlation with eGFR（r2=0.9779）； whereas no siginificant correlations were noted between them in the control group（r2=0.6762）. Conclusion The pathogenesis involved in the process of hypertensive nephropathy might be associated with a complex pathol