阳江市卵巢早衰发病原因分析.docVIP

阳江市卵巢早衰发病原因分析 　　【摘要】 目的：对阳江市女性卵巢早衰（POF）情况进行调查，分析原因，探讨预防和治疗方法。方法：调查本中心育龄妇女共9852例，对阳性的158例实施二次问卷调查，后对确诊的132例的发病因素进行统计分析。结果：导致POF的病因和发病机理分为医源性、感染、遗传、自身免疫、特发性、环境和心理6个门类，卵巢早衰的发病率为1.34%。结论：根据不同病因，实施早期干预联合行之有效的治疗方式，能够在一定程度上减少卵巢早衰的发病率，改善临床预后，值得进一步推广。 　　【关键词】 卵巢功能早衰； 相关因素； 预防 　　Analysis on Aetiological Agent of Ovarian Premature Aging in Yangjiang City/AI Hong-yun，TANG Yuan-hong，WEI Xiang-cai，et al.//Medical Innovation of China，2015，12（36）：068-071 　　【Abstract】 Objective：To investigate the situation of premature ovarian failure in females of Yangjiang city，analyze the reason and explore the prevention and treatment methods.Method：A total of 9852 women of child-bearing age in our center were surveyed.The 158 positive cases were implemented the second questionnaire，then the pathogenic factors of the 132 cases who were confirmed were statistical analyzed.Result：The etiology and pathogenesis of POF were divided into six categories，they were iatrogenic，infection，genetic，autoimmune，idiopathic，environment and psychological.The incidence of ovarian premature aging was 1.34%.Conclusion：The implementation of early intervention in combination with effective treatment according to different causes can reduce the incidence of ovarian premature aging to some extent and improve the clinical outcomes，which is worthy of further promotion. 　　【Key words】 Premature Ovarian Failure； Relevant factors； Prevention 　　First-author’s address：The Maternity and Child Care Center of Yangjiang City（Family Planning Service Center），Yangjiang 529500，China 　　doi：10.3969/j.issn.1674-4985.2015.36.023 　　卵巢早衰（Premature Ovarian Failure，POF）系女性在40岁以前出现卵巢功能减退的现象，目前国内发病率约为1%～3.8%，且发病率呈逐年上升的趋势和年轻化的趋势，其治疗困难、病因复杂，日益受到国内外临床医生的关注[1]。临床多因生殖内分泌紊乱表现为闭经、不孕、围绝经期症状等，严重威胁着女性的身心健康及生活质量。目前诊断标准：年龄40 U/L，雌激素（E2）73.2 pmol/L。病史体格检查及实验室检查作为参照[2]。POF病因多样且复杂，发病机制尚未完全阐明。目前认为多与遗传、免疫、代谢、医源性、感染有关，还受生活方式、行为习惯、精神情绪、环境因素等多种因素的调控[3]。本中心调查育龄妇女共9852例，平均年龄（35.2±3.4）岁，发现阳性例数158例，进入第2轮问卷调查，最后确诊卵巢早衰病例132例，发病率1.34%，由此可见，POF在临床上并不少见。根据对本中心调查结果的分