高血压对急性脑梗死患者血管内皮功能、同型半胱氨酸水平的影响.docVIP

高血压对急性脑梗死患者血管内皮功能、同型半胱氨酸水平的影响 　　[摘要]目的 ?^察分析高血压对急性脑梗死患者血管内皮功能、同型半胱氨酸水平的影响。方法 选取2014年6月～2016年6月在我院住院的首发急性脑梗死患者200例进行研究。将所选患者按照是否合并高血压病，分为脑梗死正常血压组（正常组）和脑梗死合并高血压组（合并组），每组各100例，并选取同期健康体检者100例为对照组。回顾性分析所选受试者FMD、IMT、血清同型半胱氨酸（Hcy）、NO、eNOS水平，并综合分析它们之间的相互关系。结果 正常组与合并组的颈动脉IMT及血清Hcy水平明显高于对照组（P0.05），而FMD及血清NO、eNOS水平明显低于对照组，差异有统计学意义（P0.05）；合并组的颈动脉IMT及血清Hcy水平明显高于正常组（P0.05），而FMD及血清NO、eNOS水平明显低于正常组，差异有统计学意义（P0.05）。Spersman直线相关分析结果显示，正常组和合并组患者IMT与血清NO、eNOS水平均成明显负相关性（P0.05），与血清Hcy水平成明显正相关性（P0.05）；正常组和合并组患者FMD与血清NO、eNOS水平均成明显正相关性（P0.05），与血清Hcy水平成明显负相关性（P0.05）。结论 急性脑梗死患者存在血管内皮功能障碍、同型半胱氨酸血症，两者和高血压在急性脑梗死的发生、发展有着重要协同关系，通过早期超声测量IMT与FMD可以预测脑梗死的发生。 　　[关键词]血流介导的舒张功能；内膜-中层厚度；急性脑梗死；高血压 　　[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721（2017）11（a）-0033-04 　　Influence of hypertension on vascular endothelial function and homocysteine level in patients with acute cerebral infarction 　　PENG Xiao-yu 　　Department of Functional Ispection，the Fourth Affiliated Hospital of Nanchang University，Jiangxi Province，Nanchang 330003，China 　　[Abstract]Objective To observe and analyze the influence of hypertension on vascular endothelial function and homocysteine level in patients with acute cerebral infarction.Methods From June 2014 to June 2016，200 patients with acute cerebral infarction in Department of Neurology in our hospital were selected for study.According to whether hypertension was combined or not，they were divided into cerebral infarction with normal blood pressure group（normal group） and cerebral infarction group with hypertension group （combined group），and 100 cases were in each group.At the same time，another group of 100 healthy people for physical examinations were selected as control group.FMD of brachial artery，IMT，and levels of Hcy，NO，and eNOS were retrospectively analyzed and their relationships were comprehensively analyzed.Results The levels of carotid IMT and serum Hcy in the normal group and the combined group were significantly higher than those in the control group （P 　　[Key words]Flow