大鼠一次性灌服酸枣仁汤剂提取物后芒果苷的药代-中国科技论文在线.PDF

1·64 · 药学学报 Acta Pharmaceutica Sinica 2005, 40 (2) : 164 - 167 Pharmacokinetics of mang iferin in rat pla sma after oral adm in istration of a single dose of Suanzaoren decoction L I Yujuan, B I Kaishun (School of Pharm acy, Shenyang Pharm aceutical U niversity, Shenyang 110016, China) Abstract: A im 　To study the pharmacokinetics of mangiferin in rats after oral adm inistration of a single dose of Suanzaoren decoction. M ethods 　An HPLC method was established using puerain as internal standard. Plasma samp les were dep roteinized with acetonitrileacetic acid ( 9 ∶1) , followed by evaporation of the acetonitrile to dryness. The resultant residue was then dissolved in mobile phase and ( μ ) HPLC separation was achieved on a Hypersil C18 200 mm ×4 6 mm ID, 5 m column at room temperature. The mobile phase consisted of acetonitrilewater ( 12 ∶88 ) with 1% acetic acid and 1% - 1 tetrahydrofuran at a flow rate of 0 7 mL ·m in . The UV detection wavelength was set at 320 nm. - 1 μ Results　The calibration curv