蜜蜂巢脾水提液的抗炎活性.PDFVIP

第30 卷第5 期 食 品 与生 物 技 术学 报 Vol. 30 No. 5 2011 年9 月 Journal of Food Scienceand Biotechnology Sept 20 11 : 1673- 1689( 20 11) 05-0648-05 蜜蜂巢脾水提液的抗炎活性 1 * 1 2 2 褚亚芳 , 胡福良 , 杨锋 , 戴关海 ( 1. 浙江大学动物科学学院, 浙江杭州310029; 2. 浙江省中医药研究院, 浙江杭州310006) : 为了研究蜜蜂巢脾对急性 症模型动物的影响, 作者以中蜂巢脾和意蜂巢脾为材料, 水提 法处理样品, 研究其对二甲苯致小鼠耳肿胀醋酸致小鼠腹腔毛细血管通透性增强和角叉菜胶致 小鼠足肿胀的影响结果表明, 中蜂巢脾水提物和意蜂巢脾水提物均显著抑制二甲苯引起的耳肿 胀, 显著降低角叉菜胶引起的足肿胀程度和局部 症组织的PGE2 含量, 对醋酸致小鼠腹腔毛细血 管通透性增强则无抑制作用此外, 中蜂巢脾水提物的抗 活性表现出剂量依赖效应 : 蜜蜂巢脾; 水提液; 抗炎; 急 炎症; PGE2 : S 8969 : A Ant-i Inflammatory Activitiesof Water Extract fromHoneycomb 1 * 1 2 2 CHU Y - f ng , HU Fu- li ng , YANG Feng , DA I Gu n-h i ( 1. College of Anim l Sciences, Zheji ng U niversit y, H ngzhou 310029, Chin ; 2. Zheji ng Inst itute of Chinese Medicine, H ngzhou 310006, Chin ) Abstract:T he im of this study is to explor e the ph rm cologic l ctivities of honeycomb g inst cute infl mm tion in nim ls, for this, the effect of w ter extr cts from Ap is cerana cerana honey comb nd A . mellif era lig ustica honeycomb on Xylene-induced e r edem , cetic cid- induced v scul r perme bility nd c rr geen n-induced hind p w edem tests in mice w er e investig ted. T he results show ed th t both s mples exhibited r em rk ble inhibition in xylene- induced e r edem model, c rr geen n-induced hind p w edem model nd the content of PGE2 in the infl mm tory tissues, w hile they show ed no nt-i infl mm tory g inst cetic cid-induced v scul r perme bility . The ph rm cologic l ctivities of the w ter extr cts of A. cer n cer n honey comb show in concentr tion-dep