颈动脉粥样硬化和冠脉病变情况相关性研究.docVIP

颈动脉粥样硬化和冠脉病变情况相关性研究 　　【摘要】 目的 研究颈动脉粥样硬化与冠心病的相关性。方法 对175例疑似冠心病的患者，均行冠脉造影和颈动脉超声检查，并根据冠状动脉造影结果分成两组：非冠心病组、冠心病组（单支病变、双支病变及三支病变），分别统计两组患者颈动脉粥样硬化的情况并分析其与冠心病的相关性。结果 发现冠心病组的颈动脉粥样硬化（CAS）等级积分和Crouse积分均明显高于非冠心病组（P均＜0.01），冠状动脉单支组和多支病变组与非冠心病组的AS指标比较差异有高度显著性（P均＜0.01）。结论 颈动脉粥样硬化与冠心病存在明显的相关性，无创的颈动脉超声检测可成为诊断冠心病的重要依据，并能初步预测冠状动脉病变的程度。 　　【关键词】颈动脉粥样硬化 冠状动脉造影术 彩色多普勒超声 　　中图分类号：R541.4 文献标识码：B 文章编号：1005-0515（2011）6-048-02 　　 　　Wang Zengshuai, Xie Rui, Chen Jie, Yan Xulong 　　(Department of Cardiovascular Medicine, the Second Affiliated Hospital of Baotou MedicalCollege, Baotou, Inner Mongolia, 014030) 　　【Abstract】Objective To study the relationship of carotid arterial atherosclerosis（CAS）and coronary heart disease（CHD）. Methods Coronary arteriography and carotid arterial ultrasound were completed in 175 cases suspected of CHD, according to the result of coronary arteriography, all the patients were divided into two groups: non-CHD group and CHD group (single，double and mutiple vessel disease)，the situation of CAS of the two groups was observed and the relationship of CAS and CHD was analyzed.Results The CAS degree score and the crouse score in group of CHD were higher than those in group of non-CHD (P＜0.01), the difference of AS indicator between the group of non-CHD and the group of single and multiple vessel disease is significant (P＜0.01).Conclusion CAS is significantly related to CHD, and the carotid arterial ultrasound could help to provide the evidence in the diagnosis of CHD and to preliminarily predict the severity of coronary artery disease. 　　【Key words】carotid arterial atherosclerosis Coronary arteriography Color Doppler ultrasound 　　 　　冠状动脉造影术是目前诊断冠心病的“金标准”，通过冠脉造影可以明确冠状动脉病变程度、病变支数等。彩色多普勒超声可以观察到颈动脉壁的特点，能准确地测量颈动脉内膜-中层厚度（intimal-medial thickness，IMT）及所形成的斑块和管腔狭窄程度，因此IMT值增高被认为是动脉硬化的早期标志[1]，可作为监测动脉硬化的一个窗口。绝大多数冠心病是由于冠状动脉粥样硬化造成的，颈动脉与冠状动脉在解剖上均是平滑肌动脉，其动脉粥样硬化的发生机制是一致的。其二者之间是否有一定的关联，近年国外的一些研究已证实颈动脉硬化与冠心病之间存在相关性 [2]。本研究通过对175例同时行冠状动脉造影及颈动脉超声检查的患者的相关资料进行统计分析，以进一步探讨文旨在进一步探讨颈动脉粥样硬化与冠心