中药修复脑线粒体防治帕金森病的研究述评.docVIP

中药修复脑线粒体防治帕金森病的研究述评 　　 摘要：帕金森病（PD）是一种常见的中枢神经系统退行性疾病，脑线粒体结构及功能异常是重要病因。目前，防治PD运用了多种中药复方、单味药、中药有效成分，其主要作用机制涉及保护线粒体形态结构、抗氧化应激、抗钙调节异常、减轻兴奋性毒性、抗细胞凋亡等，还可通过多环节、多层次、多靶点发挥综合作用。通过查阅近年具有代表性的文献，本文将中药复方、中药有效成分对脑线粒体的结构、功能修复以达到防治PD的实验研究结果进行分析、归纳，提示许多中药复方及其有效成分对PD具有良好的作用。 　　 关键词：中药;脑线粒体;帕金森病;述评 　　 DOI：10.3969/j.issn.1005-5304.2015.02.039 　　 中图分类号：R277.71 文献标识码：A 文章编号：1005-5304（2015）02-0123-04 　　Research Review on TCM Preventing and Treating Parkinsons Disease by Repairing Brain Mitochondria YANG Zhi-ming1， LI Xu-zhao1， LU Fang1， LIU Shu-min1，2 （1.Institute of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine， Harbin 150040， China;2.Drug Safety Evaluation Center， Heilongjiang University of Chinese Medicine， Harbin 150040， China） 　　 Abstract：Parkinson’s disease （PD） is a common degenerative disease of central nervous system. Brain mitochondrial dysfunction and structural damage are the important pathogeny of PD. At present， many of Chinese herbal compounds， herbal medicines， and TCM active ingredients are used to prevent and treat PD. The main mechanisms of these medicines are involved in the protection of mitochondrial structure， anti-oxidative stress， anti-calcium dysregulation， mitigation of excitotoxicity， and anti-apoptosis， etc.， which also play a comprehensive role through multi-link， multi-level， and multi-target. Through looking up the recent representative literature， the experimental results of Chinese herbal compounds and TCM active ingredients preventing and treating PD through repairing brain mitochondrial structure and function were analyzed and inducted. Many of Chinese herbal compounds and TCM active ingredients were proved to have good effects on PD. 　　 Key words：Chinese herbal medicine;brain mitochondria;Parkinson’s disease;review 　　 帕金森病（Parkinson’s disease，PD）临床主要表现为静止性震颤、肌强直、姿势平衡障碍等。随着老龄化社会来临，PD等中老年人神经退行性疾病发病率逐年升高。迄今，PD依然是一种无法防治的慢性进展性疾病[1-2]。中医对于PD的认识和治疗源远流长，中医典籍中虽无帕金森病病名，但是早在《黄帝内经》就有震颤、强直、慌张步态等症状描述。孙一奎《赤水玄珠》较早提出了以震颤为主要临床表现