卷柏属药用植物提取物体外抗柯萨奇病毒作用研究.docVIP

卷柏属药用植物提取物体外抗柯萨奇病毒作用研究 ll0中药药理与临床2007;23(5) 13罗芳,黄榕,杨于嘉,等.姜黄素预处理对大鼠感染性脑水肿的保护 作用及其机制研究.中华儿科杂志,2003;41(12):940～944 14陈绍礼.全身炎性反应综合征相关问题研究新进展.医学综述, 2006;12(15):948—950 15王涛,陈莉,孙薇,等.大鼠局灶脑缺血再灌注损伤炎性细胞因子的 变化及其意义.脑与神经疾病杂志,2001;9(1):4～5,8 16苏志达,刘平,张留宝等,实验性颅脑伤大鼠脑组织NO及NOS含 量的动态研究.南京军医学院,2001;23(3):151～153 17HopkinsSJ,RothwellNJ.Cytokinesandthenervoussystem.I:Expres— sionandrecognition.TrendsNeurosci,1995;18(2):83—88 18RothwellNJ.LuheshiG.Pharmacologyofinterleukin一1actionsinthe brain.AdvPharmacol,1994;25:1～20 19涂丰霞.肿瘤坏死因子ot与缺血性脑损伤.国际神经病学神经外科 学杂志,2006;33(3):235～239 20ZhuD.LiRLiuG.NimodipineinhibitsCa2+independentnitricoxide synthaseintransientfocalcerbralischemiaratsandcultured~troglialcel1. LifeSience.1999:65(15):221～223 21苏志达,刘平,张留宝等,实验性颅脑伤大鼠脑组织NO及NOS含 量的动态研究.南京军医学院,2001:23(3):151～153 22HauserGJ,DayaoEK,Wasser1oosK,eta1.HSPinductioninhibitsiN— OSmRNAexpressionandattenuateshypotensioninendoxin—challengedrat. Physiol,1996:271:2529～2535 EffectsofRealgarandprescriptionscontainingRealgaroninflammatory mediatorsIL—IB,IL一6,TNF一仅andNO TangYishan,WangNingsheng,ZhangYinqing (InstituteofClinicalPharmacology,GuangzhouUniversityofChineseMedicine,Guangzhou510405) objective:ToexplorethepharmacologicalmechanismofRealgarbywayofstudyingtheeffectsofRealgarandprescriptionscontaining RealgaroninflammatorymediatorsIL一1B,IL一6,TNF—andNOunderpathologicstatus(infectiouscerebralinjurymodelandfevermod— e1).Methods:Inexperiment1,SDratswererandomlydividedintosixgroups,and6ratsineachgroup:untreatednormalgroup,infectious cerebralinjurymodelgroup,modelratsadministratedbyRealgaroflow,middle,highdosage(75mg/kg,150mg/kg,300mg/kg)andAngong Niuhuangpowder(ANP,1.5kg).Bloodsamplesandbraintissueswerecollectedat3hafteradministration.Inexperiment2,SDrats wererandomlydividedintofourgroups,and15ratsineachgroup:untreatednormalgroup,fevermodelgroup,modelratsadministratedby Realgar(90mg/kg)andNiuhuangJieduTablet(NJT,1.404g/kg).Eachgroupwasdividedintothreesubgroups(5rats/subgroup).Blood samplesoftheratsinsubgroupswerecollect