医学毕业论文--异种骨椎间融合器椎弓根钉固定腰椎体间融合术的生物力学评价.doc

PAGE \* MERGEFORMAT 1 异种骨椎间融合器椎弓根钉固定腰椎体间融合术的生物力学评价 作者：程维　赫兰学　郑昊　马洪顺　李晓华　李德江 李长有　张俊峰　徐松宝　宋扬 王宏家 【关键词】 异种骨椎间融合器 摘要：［目的］评价异种骨椎间融合器行后路腰椎椎体间融合的即刻稳定效果及自身强度。［方法］取16具新鲜成年男性L1~5腰椎标本，分别对完整L1~5（正常组）；模拟后路间盘L3、4摘除置融合器（对照1组）；模拟后路间盘L3、4、L4、5摘除置融合器（对照2组）；模拟后路间盘L3、4摘除置融合器附加椎弓根钉固定（对照3组）；模拟后路间盘L3、4、L4、5摘除置融合器附加椎弓根钉固定（对照4组）进行前屈、后伸、扭转、轴向压缩和腰椎移位时融合器的最大拨出力及粘弹性实验研究。［结果］显示椎间融合器植入后腰椎压缩、前屈、后伸、位移和扭转角度较正常组有一定差异，但不显著（P＞005）；而椎间植入融合器附加椎弓根固定，压缩、前屈、后伸、位移、扭转角度较正常组差异显著（P＜005）。腰椎移位时拨出力实验结果表明，对照1、2融合器植入椎体移位时最大拨出力为183 KN。对照1、2、3、4组7 200s三应力松驰量和蠕变量较正常组差异不显著（P＞005）,对照3、4组初始蠕变量明显低于正常组和（1、2组）。［结论］异种骨椎间融合器具有足够的支撑、抗滑、维持或增加椎间隙高度的功能，符合生物力学及临床要求。 　　关键词：腰椎；异种骨椎间融合器；椎弓根钉固定；生物力学；稳定性；粘弹性 　　Biomechanical evaluation on intervertebral fusion by intervertebral heterogenous bone fusion cage with pedicular fixation 　　Abstract：［Objective］To evaluate the immediate stability effect and strength of the intervertebral heterogenous bone fusion cage for lumbar intervertebral fusion［Method］Sixteen male L1~5 specimens were divided into five groups:group A,L3~4 disc excision +fusion cage;group B,L3~4,L4~5disc excision +fusion cage;group C,L3~4disc excision +fusion cage with pedicular fixation;group D,L3~4L4~5disc excision +fusion cage with pedicular fixation and control group,normal L3~4,L4~5The maximum pull strength on fusion cage,viscoelastic properties,creep function and lumbar loadingdisplacement curve were tested during lumbar flexion and extension,axial compression and left and right torsion［Result］1The change of axial compression,flexion and extension,loading displacement and torsion angle showed no statistic significance (P＞005) between control group and group A,group B,but obvious significance between control group and group C and D;2The maximum pull strength on cage of group A and B was 185 KN during lumbar displacement;3There was no statistic significance in the stress relaxation and creep between groups A,B,C,D and control group (P＞005),but initial creep function was lower obviously than that of control group［Conc