5785例儿童乙型肝炎病毒表面抗体定量检测的的结果分析.docVIP

5785例儿童乙型肝炎病毒表面抗体定量检测的的结果分析 　　【摘要】 目的：了解儿童人群对HBV抵抗能力的特点和现状。方法：对2013年1月1日-2014年12月31日本院门诊和住院部的0～14岁儿童定量检测乙型肝炎病毒表面抗体的结果进行分析。结果：各年龄组乙型肝炎病毒表面抗体定量结果分布不服从正态分布。乙型肝炎病毒表面抗体定量检测结果各年龄组均值比较，差异有统计学意义（P0.05）。结论：（1）各年龄组乙型肝炎病毒表面抗体定量值不服从正态分布，年龄越小，离散程度越大。（2）0～3岁儿童由母体得到的乙型肝炎病毒表面抗体由较高水平达到最低值；同时自身生成的抗体在增长。3～5岁维持在低水平，之后免疫能力逐渐增强，应重视9～10岁儿童乙型肝炎病毒表面抗体浓度的监测并加强HBV疫苗注射，提高免疫能力。（3）2.01～3岁组和12.01～13岁组男女比较存在的差别契合男女儿童身体发育的特点。 　　【关键词】 乙型肝炎病毒表面抗体； 定量检测； 儿童 　　【Abstract】 Objective：To investigate the characteristics and current state of children’s resistance to the HBV.Method：The quantitative results of HBsAb in the 0 to 14 year-old children in the outpatient department and the hospitalized department of our hospital from January 1，2013 to December 31，2014 were analyzed.Result：The distribution of the HBsAb quantitative results among all age groups didn’t obey normal distribution.The differences in the mean valuces of HBsAb quantitative results among all age groups were statistically significant（P0.05）.Conclusion：（1）The distribution of the HBsAb quantitative results among all age groups doesn’t obey normal distribution，the younger，the greater the degree of discrete.（2）In 0-3 year-old children，the HBsAb obtained from matrix drops from a higher level to the lowest，the own generate antibodies increases at the same time.The distribution of the HBsAb maintains at low level in the 3-5 year-old group，then the immune function enhances gradually.The monitor of the distribution of HBsAb and the injection of HBV vaccine shall be strengthen in order to improve the immune ability（3）The differences in the 2.01-3 years group and 12.01-13 years group are agreed with the characteristics of the male and female children’s physical development. 　　【Key words】 HBsAb； Quantitative test； Children 　　First-author’s address：The First People’s Hospital of Nanyang City，Nanyang 473000，China 　　doi：10.3969/j.issn.1674-4985.2016.07.015 　　乙型肝炎是由乙型肝炎病毒（Hepatitis B virus，HBV）感染引起的一种传染性疾病。我国属于HBV高流行区。2006年流行病学调查显示，我国HBV感染流行率达34.28%，