过敏性疾病免疫治疗国际共识-2015-解读-李全生.pdfVIP

CHIN ARCH OTOLARYNGOL HEAD NECK SURG / October 2016, Vol.23, No.10 569 DOI: 10.16066/j.1672-7002.2016.10.004 免疫治疗专题：方案指南解读 过敏性疾病免疫治疗国际共识（2015）解读 1 2 1 3 李全生 ，林小平，魏庆宇，张罗 1 解放军第二○二医院过敏反应科，辽宁　沈阳　110003；2 沈阳军区总医院变态（过敏）反应科，辽宁　沈阳　110016；3 首都 医科大学附属北京同仁医院耳鼻咽喉头颈外科，耳鼻咽喉头颈科学教育部重点实验室（首都医科大学），北京市耳鼻咽喉科研 究所，鼻病研究北京市重点实验室，北京　100005 [ 摘 　 要 ] 　 自2 0 世纪初期特异性过敏原免疫治疗 Otolaryngology Head and Neck Surgery(Capital Medical （allergen-specific immunotherapy，ASIT ）就已被用来 University), Ministry of Education, Beijing Institute of 治疗过敏性疾病。尽管大量的临床试验和Meta分析证明 Otolaryngology, Beijing Key Laboratory of Nasal diseases, ASIT 的有效性，但是ASIT仍然得不到广泛的应用。ASIT Beijing, 100005, China 是唯一能够改变过敏性疾病自然病程的治疗措施，表现在 C o r r e s p o n d i n g a u t h o r : Z H A N G L u o ( E m a i l : 能够预防哮喘的发生和新的过敏原致敏以及诱导机体对特 dr.luozhang@139.com) 异性过敏原的免疫耐受。因此，制定一个详细广泛的ASIT [ABSTRACT]　 Allergen-specific immunotherapy(ASIT) 共识是非常重要的。本文通过对ASIT 国际共识的解读，为 has been used to treat allergic disease since the early 临床医师采用免疫治疗过敏性疾病提供帮助。 1900s. Despite numerous clinical trials and meta-analyses [关键词]　免疫疗法；鼻炎，变应性，常年性；鼻炎，变应 proving ASIT efficacious, it remains could not get a wide 性，季节性；哮喘；皮炎，特应性；食物过敏 range of applications. The elaboration of a wider consensus is of utmost importance because ASIT is the only treatment Interpretation of international consensus on allergy that can change the course of allergic disease by preventing immunotherapy(2015) the development of asthma and new allergen sensitizations 1 2 1 3 LI Quansheng , LIN Xiaoping , WEI Qingyu , ZHANG Luo and by inducing allergen-specific immune tolerance. In 1