保肝消脂冲剂治疗脂肪肝52例临床的研究.docVIP

保肝消脂冲剂治疗脂肪肝52例临床的研究 　　[摘要] 目的: 评价以疏肝健脾利湿降浊法组方的保肝消脂冲剂治疗脂肪肝的临床疗效。方法：对确诊为脂肪肝的52例患者，随机分为治疗组和对照组。治疗组28例，对照组24例。治疗组服用保肝消脂冲剂，对照组服用东宝肝泰片。疗程为8周，观察治疗前后临床症状，肝脏超声，肝功能及血脂的变化。结果：治疗组总有效率为92.9％，对照组总有效率为75％，两组比较具有显著性差异（P0.05）。结论：以疏肝健脾利湿降浊法组方的保肝消脂冲剂治疗脂肪肝的疗效强于东宝肝泰片，是治疗脂肪肝的有效药物。 　　[关键词] 保肝消脂冲剂；脂肪肝；临床研究 　　[中图分类号] R256.4[文献标识码]B [文章编号]1673-7210（2008）02（c）-074-02 　　 　　Treatment of fatty liver of 52 cases by Baoganxiaozhi Granula 　　XIE Jing-ri, DONG-Qun, LI-Ming 　　（The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Mdeicine,Harbin 150040,China） 　　[Abstract] Objective: To appraise the curative effect of Baoganxiaozhi Granula which is based on the method of disperse the depressed liver-energy, invigoratethespleen, dampeliminationanddescendingurination for fatty liver.Methods: 52 cases of fatty liver were allocated to 2 group randomly(the treatment group was 28,the control group was 24). The treatment group was treated by Baoganxiaozhi Granula, the control group by Dongbaogantai Pellet, with a course of 8 weeks. The clinical symptom, ultrasonic examination of liver, liver function and the changes of blood-fat before and after treatment were observed.Results: The total effective rate of the treatment group was 92.9％, and the control group was 75％. the comparison of various parameters between treatment group and control group showed markedly significant difference(P0.05). Conclusion:Baoganxiaozhi Granula is rather effective for fatty liver disease． 　　[Key words] Baoganxiaozhi Granula;Fatty liver;Clinical research 　　 　　脂肪肝是指由于多种原因引起的中性脂肪在肝细胞内的过多蓄积，是一种常见的肝脏代谢性疾病[1]。随着人们生活水平的不断提高、高脂类食物及酒精摄入量的明显升高，脂肪肝的发病率也在逐年增加。另外，由于现代检查手段的广泛应用，使脂肪肝患者的检出率也逐年升高[2]。现在人们对脂肪肝的认识越来越清楚，脂肪肝所引起的肝脏损伤及导致肝硬化等方面的危害也越来越引起人们的重视。然而，现代医学在脂肪肝治疗方面仍无理想药物，而且许多药物毒副作用较多，难以为患者所接受，相比之下，中医药治疗脂肪肝有其独到之处，对其防治有着显著的疗效[3]。 　　保肝消脂冲剂是在中医理论疏肝健脾利湿降浊法基础上研制开发的纯中药制剂，对脂肪肝有着确切的治疗作用。本研究从临床观察方面对保肝消脂冲剂的作用机制及疗效进行探讨，现将结果总结如下： 　　1 资料和方法 　　1.1 一般资料 　　病例选择2006年8月～2007年4月在我院住院及门诊收治的脂肪肝患者共52例。诊断均符合中华医学会脂肪肝和酒精性肝病学会组制定的诊断