近视分子致病机制与干预措施研究进展.PDFVIP

第11卷第11 期 Vol.11 No.11 2018 年6 月 June 2018 近视的分子致病机制及干预措施研究进展 郭 芳，魏瑞华，吴绵绵，孙笑笑，张 琰* （天津医科大学眼科医院，天津医科大学眼科研究所，天津医科大学眼视光学院，天津 300384 ） 摘要：近视是一种常见的屈光不正，危害身心健康。为有效防控近视，探索其致病机制迫在眉睫。但近视的致 病机制仍不明确。自 20 世纪 70 年代发展至今，近视动物模型的建立与发展在分子机制、干预措施等方面为 实现近视防控的目标提供了有力支持。如何合理应用近视动物模型与人类近视相联系，仍然是研究的重点与 难点。本文就近视常见分子致病机制及干预措施的研究进展做一综述，通过阐释近视的研究成果，为近视的 防控提供新思路。 关键词：眼科学；近视；综述；干预措施；致病机制 中图分类号：R778.1+1 文献标识码：A 文章编号：1674-2850(2018)11-1065-10 Research progress on molecular pathogenesis and interventions of myopia GUO Fang, WEI Ruihua, WU Mianmian, SUN Xiaoxiao, ZHANG Yan (Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin 300384, China) Abstract: Myopia has become a common refractive error, endangering physical and mental health. In order to effectively prevent and control myopia, exploring its pathogenesis is imminent. However, the pathogenesis is still not clear. Since the 1970s, the establishment and development of myopic animal models has provided strong support for achieving the goal of the myopia prevention and control from the perspective of molecular mechanism, interventions, etc. There exists a research hotspot and difficulty that how to apply reasonably myopic animal models for matching human myopic. In this paper, the research progress on myopic common molecular pathogenesis and interventions will be reviewed, which may provide new ideas for the myopia