加味黄芪桂枝五物汤外洗治疗奥沙利铂致周围神经病变临床的研究.docVIP

加味黄芪桂枝五物汤外洗治疗奥沙利铂致周围神经病变临床的研究 　　摘要：目的 观察加味黄芪桂枝五物汤外洗对奥沙利铂引起的慢性周围神经病变的临床疗效。方法 将60例奥沙利铂化疗引起周围神经病变患者随机分为对照组和治疗组各30例。2组均予甲钴胺注射液治疗（0.5 mg/d，每周3次），治疗组同时予加味黄芪桂枝五物汤外洗，疗程均为14 d。观察2组临床疗效及不良反应。结果 治疗组总有效率为73.3%（22/30），对照组总有效率为40.0%（12/30），2组比较差异有统计学意义（P0.05）。2组患者均未见不良反应发生。结论 加味黄芪桂枝五物汤外洗可有效干预奥沙利铂引起的慢性周围神经病变。 　　关键词：奥沙利铂；周围神经病变；黄芪桂枝五物汤 　　DOI：10.3969/j.issn.1005-5304.2015.11.004 　　中图分类号：R277.75 文献标识码：A 文章编号：1005-5304（2015）11-0013-03 　　Clinical Study on External Bath of Modified Huangqi Guizhi Wuwu Decoction for Peripheral Neurotoxicity Induced by Oxaliplatin SHEN Jie1， HE Sheng-li1， SUN Xian-jun2， HU Nan-hua1， CAI Yun-yun1 （1.Department of Integrated Traditional Chinese and Western Medicine， Minhang Branch of Fudan University of Shanghai Cancer Center， Shanghai 200240， China；2.Medical Intervention Center， Tongren Hospital， Shanghai 200050， China） 　　Abstract：Objective To observe clinical efficacy of external bath of modified Huangqi Guizhi Wuwu Decoction in relieving peripheral neurotoxicity induced by oxaliplatin. Methods Sixty patients were randomly divided into control group and treatment group （30 cases in each group）. Both groups received intramuscular injection of mecobalamine （0.5 mg/d， three times a week）. At the same time， the treatment group received external bath of modified Huangqi Guizhi Wuwu Decoction. All the courses of treatment lasted for 14 days. Clinical efficacy and adverse reactions of the two groups were observed. Results The total effective rate of treatment group was 73.3% （22/30）， which was superior to that of 40.0% （12/30） in the control group， with statistical significance （P0.05）， without any adverse reaction. Conclusion External bath of modified Huangqi Guizhi Wuwu Decoction is effective as supportive care for alleviating chronic peripheral neurotoxicity induced by oxaliplatin. 　　Key words：oxaliplatin；peripheral neurotoxicity；Huangqi Guizhi Wuwu Decoction 　　奥沙利铂引起的周围神经病变不仅会影响患者对化疗的耐受性，甚至可以演变成严重、持久的影响患者生活质量的不良事件。迄今为止，针对奥沙利铂周围神经病变几乎不存在公认的防治方案[1]，特别