子宫内膜异位症患者血清中微量元素变化的研究.docVIP

子宫内膜异位症患者血清中微量元素变化的研究 　　[摘要] 目的:探讨子宫内膜异位症患者(endomethiosis,EMT)血清中微量元素含量变化的特点。方法:2002～2005年,采集我院子宫内膜异位症患者和健康妇女肘静脉血各5 ml,离心后取其血清用等离子体发射光谱仪测定并进行统计学处理。结果:子宫内膜异位症患者血清中的Se、Cr、Mn、Fe、Cu、Zn的含量与健康妇女比较,Se和Cr的含量降低,而Fe、Zn、Cu和Mn的含量升高,两组比较,有显著性和高度显著性差异(P0.05和P0.01)。结论:为控制和缓解本症患者的病状,应对其补充降低的元素、降低升高的元素,使体内元素的含量趋于正常和平衡。 　　[关键词] 子宫内膜异位症;血清;微量元素 　　[中图分类号] R711.71 [文献标识码]A [文章编号]1674-4721(2010)04(b)-037-02 　　 　　Variation of serum microelements in the patients with endometriosis 　　LUO Jin, GE Hua 　　(Gynaecology and Obstetrics Department of the First Affiliated Hospital, Baotou Medical College of Inner Mongolia of Science and Technology, Baotou 014010, China) 　　[Abstract] Objective: To explore the variation of serum microelements in the patients with endometriosis. Methods: 5 ml venous blood was acquisitioned each from endometriosis patients and healthy women elbow from 2002 to 2005 in our hospital. After centrifugation, whichever serum was measured by plasma emission spectrometer, and then statistical analyzed. Results: Se and Cr contents in serum of patients were lower and Mn、Fe、Cu、Zn contents were higher than that of healthy women. There were significant difference (P0.05) and highly significant difference (P0.01). Conclusion: It is necessary that microelement contents of patients should be keep in equilibrium by supplementing the microelement decreased and lowering microelements content increased in order to control and relieve symptom of endometriosis. 　　[Key words] Endometriosis; Serum; Microelement 　　 　　子宫内膜异位症(endomethiosis,EMT)是一种始于细胞水平而终止于以盆腔疼痛和不孕为特点的持续性病变。其发病机制的研究虽有多种学说,尚难完全阐明病变的确切原因。因此,EMT已成为目前国内外妇产科的常见病、多发病和难治之症,攻克此症仍是面临的艰巨任务。为此,笔者从微量元素角度对其体内微量元素的含量变化进行探讨,以寻求新的防治措施。 　　1 对象与方法 　　1.1 对象 　　子宫内膜异位症患者属包头地区常住居民。经妇科手术或腹腔镜探查明确诊断,并通过病理学证实者,共计188例,年龄最小24岁,最大41岁,平均32.3岁。另选包头地区健康未孕妇女212名,作为对照组,平均年龄26岁。 　　1.2 方法 　　1.2.1 血样前处理分析使用的全部化学试剂均为优级纯、使用的全部容器、量具清洗后置于分析纯的1∶1硝酸溶液中24 h,取出后用自来水冲洗5遍,再用蒸馏水和去离子水各冲洗3遍、烘干,保存备用。准确量取血清1.5 ml,放于石英坩锅内,加入混合酸(硝酸∶高氯酸=3∶1)5 ml,加盖玻璃片,静置24 h,再置于可调温的电